| 肝脾康颗粒成型工艺研究 |
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| 引用本文： | 阎敏,肖炼红.肝脾康颗粒成型工艺研究[J].中国药业,2009,18(19):41-42. |
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| 作者姓名： | 阎敏 肖炼红 |
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| 作者单位： | 1. 中南大学湘雅医院药剂科,湖南,长沙,410008
2. 湖南康普制药有限公司,湖南,长沙,410008 |
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| 摘 要： | 目的确定肝脾康颗粒的最佳制粒处方组成。方法以颗粒吸湿百分率、成型率和溶化率为指标,筛选颗粒的最佳辅料与配比。结果处方最佳组成为3份浸膏粉与3份辅料（蔗糖∶糊精=2∶1的混合辅料）;所制颗粒的吸湿率小、成型率高、溶化率高。结论试验结果可为肝脾康颗粒制剂处方组成的确定提供依据。
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| 关 键 词： | 肝脾康颗粒 成型工艺 临界相对湿度 |
Study on Formulation Process of Gangpikang Granule |
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| Yan Min,Xiao Lianhong.Study on Formulation Process of Gangpikang Granule[J].China Pharmaceuticals,2009,18(19):41-42. |
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| Authors: | Yan Min Xiao Lianhong |
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| Institution: | 1. Xiangya Hospital of Central South University, Changsha, Hunan, China 410008; 2. Hunan Kangpu Pharmaceutical Co., Ltd., Changsha, Hunan, China 410008) |
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| Abstract: | Objective To ascertain the best granulation formulation process of Ganpikang Granule. Methods By determining hygroscopicity, granulation and dissolubility as the indexes, the optimal excipient and its formula were screened. Results The best excipient and its formula were three extract powders and three excipients which consisted of sucrose and dextrin （2：1, W/W）. The made granules had low hygroseopicity, high granulation and high dissolubility. Conclusion The experimental results provide the basis of the ascertainment of formulation orocess and the control of production environment of Ganoikang Granule. |
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| Keywords: | Ganpikang Granule formulation process critical relative humidity |
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