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Upregulation of CREM-1 Relates to Retinal Ganglion Cells Apoptosis After Light-Induced Damage In Vivo |
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| Authors: | Yue Xu Shanshan Yu Qinmeng Shu Lu Yang Cheng Yang Jiawei Wang Fan Xu Min Ji Xiaoling Liang |
| Affiliation: | 1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong Province, People’s Republic of China 2. Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, People’s Republic of China 3. Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, People’s Republic of China 4. Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China |
| Abstract: | Previous studies have shown activation of cyclic AMP response element-binding protein (CREB) family is involved in the retinal ganglion cells (RGCs) protection. However, the function of cyclic AMP response element modulator-1 (CREM-1), one member of the CREB family, is still with limited acquaintance. To investigate whether CREM-1 is involved in RGCs death, we performed a light-induced retinal damage model in adult rats. Upregulation of CREM-1 was observed in retina after light-induced damage by performing western blot. Immunofluorescent labeling indicated that upregulated CREM-1 was localized mainly in the RGCs. We also investigated co-localization of CREM-1 with active-caspase-3 and TUNEL (apoptotic markers) in the retina after light-induced damage. In addition, the expression patterns of B cell lymphoma/leukemia-2 and Bcl-2 associated X protein were parallel with that of CREM-1. Collectively, we hypothesized upregulation of CREM-1 in the retina was associated with RGCs death after light-induced damage. |
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