Four new HLA class I alleles in Cauacasoids |
| |
Authors: | Alonso-Nieto M García-Sánchez F Lillo R Balas A Blanco L Aviles-Egea M J Zarapuz L Vicario J L |
| |
Institution: | Laboratory of Histocompatibility, Regional Transfusion Center, Madrid, Spain. |
| |
Abstract: | Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30-specific Ser17. B*270505 differs from B*270502 in a silent substitution at an up to now constant position in the B locus. B*3541 encodes for a new Cys at position 118 that has not been encountered in neither human nor primate alleles. Cw*0716 seems to be originated by a large-scale interallelic recombination event between Cw*0701/*0706/*0718 and Cw*020202, giving rise to a new antigen-binding cleft conformation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|