T淋巴细胞在器官缺血/再灌注损伤中的作用

器官缺血/再灌注(ischemia/reperfusion,I/R)损伤是一种复杂的、多因素参与、非抗原依赖性炎症反应,对器官功能的早期和远期影响以及患者的生命安全有重要的影响,也是目前阻碍器官移植发展的一道难题.传统的理论认为器官I/R损伤主要是固有性免疫系统参与的,如巨噬细胞、中性粒细胞等.但是在近几年的研究中,人们发现适应性免疫系统在器官I/R损伤中也发挥着重要的作用,尤其是T淋巴细胞.T淋巴细胞主要在再灌注后1 h内浸润,通过分泌因子和调节其他炎症细胞浸润引起器官I/R损伤.

Effects of T lymphocyte in organ ischemia/reperfusion injury

lschemia/reperfusion (I/R) injury is a complex, multi-factorial, and antigen-independent inflammatory response. It may result in organ dysfunction in the early and long-term phase, and sometimes be life-threatening. It is also a significant clinical problem interfering the development of the organ transplantation. In traditional theory, the innate immunity such as macrophage and neutrophil play the main role in organ ischemia/reperfusion injury. However in recent experiments investigators found that the adaptive immunity also plays a significant role in organ ischemia/reperfusion injury, especially the T lymphocyte. The T lymphocyte infiltrated into the organ at 1 h after reperfusion, and induced the ischemia/reperfusion injury by the secretion of cytokine and by regulating the infiltration of other inflammatory cell.