甲状腺自身抗体在自身免疫性甲状腺疾病诊断中的临床应用

目的 探讨患者血清甲状腺自身抗体——促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)浓度的变化,在自身免疫性甲状腺疾病(AITD)中桥本甲状腺炎(hashimoto,HT)和毒性弥漫性甲状腺肿(Graves' disease,GD)的诊断意义.方法 选取2015年2月至8月我院收治200例患者,其中桥本甲状腺炎100例,Graves病100例,以及50例健康志愿者作为对照组.采用电化学发光法(ECLIA)检测TRAb,用放射免疫法(RIA)检测TPOAb和TGAb,并对比上述指标的检测结果.结果 自身免疫性甲状腺疾病(AITD)显著高于健康对照组,Graves病患者TRAb水平显著高于桥本甲状腺炎患者,而且桥本甲状腺炎患者TPOAb、TGAb水平显著高于Graves病患者,均有显著差异(P＜0.05).结论 TPOAb、TGAb在桥本甲状腺病诊断中起重要作用.而TRAb对于Graves病有较高的灵敏度和特异性,可以作为诊断Graves病的特异性指标.

Clinical Value of Thyroid Autoantibodies in the Diagnosis of Autoimmune Thyroid Disease

Objective To investigate the value of serum thyroid autoantibodies,TRAb,TPOAb and TGAb in the diagnosis of Hashimoto and Graves' Disease of autoimmune thyroid disease.Methods We enrolled 100 cases of Hashimoto and 100 cases of Graves' Disease and 50 healthy controls in our department between February 2015 to August 2015.The serum TRAb levels were detected by electrochemical luminescence (ECLIA),and the serum levels of TPOAb and TGAb were detected by radioimmunoassy(RIA).The results of three indexes were compared among the three groups.Results Thyroid autoantibodies was significantly higher than that of healthy control group.TRAb in Graves' Disease was significantly higher than that of the Hashimoto,the serum levels of TPOAb and TGAb in Hashimoto was significantly higher than that of the Graves' Disease.All differences were statistically significant (P ＜ 0.05).Conclusion The serum levels of TPOAb,TGAb may play an important in Hashimoto Disease.The serum levels of TRAbis sensitive in the diagnosis for Graves Disease,which can be used as a diagnostic index in Graves' Disease.