| 纳洛酮对离体大鼠心脏缺血再灌流损伤的保护作用 |
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| 引用本文： | 卢宁平,吴吉茂.纳洛酮对离体大鼠心脏缺血再灌流损伤的保护作用[J].中国药理学通报,1993,9(6):446-448. |
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| 作者姓名： | 卢宁平 吴吉茂 |
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| 作者单位： | 宜春医专病理生理教研室 宜春336000
(卢宁平)，江西医学院病理生理教研室 南昌330006(吴吉茂) |
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| 摘 要： | 本实验采用离体大鼠心脏Langendorff灌流装置.使心脏停灌(旷置)40 min后再恢复灌流30min.夏制心肌缺血再灌流损伤.观察了纳洛酮对再灌流后冠脉流出液中乳酸脱氢酶(LOH)活性,心肌细胞内钙含量.心肌脂质过氧化产物——丙二醛(MDA)含量和超氧化物歧化酶(SOD)活力变化的影响。结果表明.再灌流后应用纳洛酮能显著减少心肌LDH的释放量.心肌细胞内钙聚集、心肌MDA的生成量及SOD活力降低的程度.提示纳洛酮对缺血再灌流心肌具有保护作用。
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| 关 键 词： | 纳洛酮 心肌 缺血再灌流 |
Protective effects of naloxone on the myocardial postischemic reperfusion injury in isolated rat hearts |
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| LU Ning-Ping,WU Ji-Mao.Protective effects of naloxone on the myocardial postischemic reperfusion injury in isolated rat hearts[J].Chinese Pharmacological Bulletin,1993,9(6):446-448. |
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| Authors: | LU Ning-Ping WU Ji-Mao |
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| Institution: | LU Ning-Ping,WU Ji-Mao1 |
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| Abstract: | In the Langendorff's perfused isolated rat hearts, the myocardial postischemic reperfusion injury was induced by reperfusion for 30 min after stoppage of perfusion for 40 min. The effects of naloxone on the lactic acid dehydrogenase (LDH) content, the myocardial Ca contents, the myocardial malondialdiehyde (MDA) production and the myocardial superox-ide dismutase (SOD) activity were observed
during reperfusion. The results show that naloxone significantly decreased cardiac LDH release, attenuated myocardial Ca accumulation, reduced MDA production and prevented redution of SOD activity in comparison with the control in perfused isolated rat hearts with global ischemia (40 min) and reperfusion (30 min). It suggests that naloxone has protective effects on myocardial reperfusion injury. |
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| Keywords: | Naloxone Myocardium Ischemia and reperfusion |
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