| HPLC法测定甘油果糖注射液中5-羟甲基糠醛 |
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| 引用本文： | 于海云,孔静. HPLC法测定甘油果糖注射液中5-羟甲基糠醛[J]. 齐鲁药事, 2009, 28(3): 144-146 |
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| 作者姓名： | 于海云 孔静 |
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| 作者单位： | 山东齐都药业有限公司,山东,淄博,255400 |
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| 摘 要： | 目的建立高效液相色谱法测定甘油果糖注射液的5-羟甲基糠醛。方法采用十八烷基硅烷键合硅胶为填充剂;以甲醇-0.1%枸橼酸溶液(25∶75)为流动相;检测波长为284nm。结果5-羟甲基糠醛在浓度为1.0～20.0μg·mL-1范围内与峰面积具有良好的线性关系(r=0.9982)。结论该方法操作简便,精密度高,结果准确可靠。
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| 关 键 词： | 高效液相色谱法 甘油果糖注射液 5-羟甲基糠醛 |
Determination of 5-Hydroxymethylfurfural in Glycerol and Fructose Injection by HPLC |
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| YU Hai-yun,KONG Jing. Determination of 5-Hydroxymethylfurfural in Glycerol and Fructose Injection by HPLC[J]. qilu pharmaceutical affairs, 2009, 28(3): 144-146 |
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| Authors: | YU Hai-yun KONG Jing |
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| Affiliation: | Shandong Qidu Pharmaceutical Limited Company;Zibo 255400 |
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| Abstract: | OBJECTIVE To establish a method for the control of related substances in Glycerol and Fructose Injection. METHODS A Phenomenex C18 Column was used with the mobile phase of methonal -0.1% citric acid （25 ： 75）. The determi- nation wavelength was 284nm. RESULTS The calibration was linear within the concentration range of 1.0-20.0μg·mL^-1（ r=0.9982）. CONCLUSION The method was slmple,accurate and specific,it can be used for the quality control of the products. |
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| Keywords: | HPLC Glycerol and Fructose Injection 5-Hydroxymethylfurfural |
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