Lifetime psychopathology among the offspring of Bipolar I parents |
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Authors: | Zappitelli Marcelo C Bordin Isabel A Hatch John P Caetano Sheila C Zunta-Soares Giovana Olvera Rene L Soares Jair C |
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Institution: | 9. Department of Psychiatry, Federal University of Sã Paulo, Sã Paulo, Brazil.;99. Departments of Psychiatry and Orthodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.;999. Department of Psychiatry, Faculdade de Medicina da Universidade de Sã Paulo, Sã Paulo, SP, Brazil.;9V. University of Texas Health Science Center at Houston, Houston TX, USA.;V. Division of Child and Adolescent Psychiatry, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. |
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Abstract: | BACKGROUND:Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents.METHOD:This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5±2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated.RESULTS:Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%).CONCLUSIONS:Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
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Keywords: | Bipolar Disorder Offspring Psychopathology Child Adolescent |
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