Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20 |
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| Authors: | J Gonin H Kadiri S Bensaci A Le Tourneau T J Molina J Diebold D J Abdellouche J Audouin |
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| Institution: | 1.Service Central d’Anatomie et Cytologie Pathologiques,“Jacques Delarue”, H?tel-Dieu,Paris Cedex 04,France;2.Département de pathologie,Centre Hospitalier,Sétif,Algéria |
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| Abstract: | We describe an unusual case of ALK-1-positive primary mediastinal lymphoma with the morphology of an anaplastic large-cell
lymphoma (ALCL) of T/NK cell type but expressing CD20. This tumour had T/NK morphology and immunophenotype, as demonstrated
by its expression of CD30, EMA, ALK-1, CD7 and TiA-1 and the lack of expression of B-cell markers other than CD20. The significance
of such a co-expression of a B cell-associated antigen in a case of ALCL of T/NK cell type is discussed. |
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| Keywords: | Anaplastic ALK-1 positive large-cell lymphoma T/NK Aberrant CD20 expression Mediastinum lymphoma |
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