美托洛尔联合甲巯咪唑治疗甲状腺功能亢进症合并心房颤动患者的效果观察

目的探讨美托洛尔联合甲巯咪唑在甲状腺功能亢进症合并心房颤动患者中的应用效果。方法选择2010年10月～2012年10月在浙江省东阳市横店医院收治的98例甲状腺功能亢进症合并心房颤动患者为研究对象，运用随机数字表法将符合本研究纳入标准和排除标准的患者分为A组和B组，每组各49例，A组患者给予美托洛尔联合丙基硫氧嘧啶治疗，B组患者给予美托洛尔联合甲巯咪唑治疗，比较两组患者治疗前后游离三碘甲腺原氨酸（fT3）、游离甲状腺素（fT4）水平、心率（HR）的变化、治疗疗效和药物副作用。结果B组患者的治疗总有效率明显优于A组，差异有统计学意义（P〈0．05），B组患者fT3、fT4和HR明显低于A组，差异有统计学意义（P〈0．05），但是两组患者在药物不良反应发生率方面差异无统计学意义（P〉0．05）。结论美托洛尔联合甲巯咪唑治疗甲状腺功能亢进症合并心房颤动能够明显改善患者的临床症状和降低患者fT3、fT4和HR，临床疗效确切，优于美托洛尔联合丙基硫氧嘧啶，该方案具有安全可靠和不良反应少等特点，值得进一步推广。

Observation on clinical efficacy of thyrotoxicosis patients merging atrial fibrillation by Metoprolol Tartrate combined with Thiamazole

Objective To explore the clinical efficacy and safety of hyrotoxicosis patients merging atrial fibrillation by Metoprolol Tartrate combined with Thiamazole. Methods 98 thyrotoxicosis patients merging atrial fibrillation, who were treated in Hengdian Hospital of Dongyang City from October 2010 to October 2012 were chosen as the research object, then they were divided into group A and group B by a random number table with 49 cases in each group, patients in group A were given Metoprolol Tartrate Tablets combined with Propylthiouracil, patients in group B were given Metoprolol Tartrate Tablets combined with Thiamazole, the iT3, fT4, HR, clinical efficacy and drug side effects were compared. Results The clinical efficacy of group B was better than that in group A （P 〈 0.05）, the fT3, fT4, HR, clinical efficacy of group B were lower than those in group A （P 〈 0.05）, the adverse drug reactions of group B did not increase significantly （P 〉 0.05）. Conclusion The clinical efficacy and safety of thyrotoxicosis patients merging atrial fibrillation by Metoprolol Tartrate Tablets combined with Thiamazole can significantly improve patients＇ clinical symptoms and reduce the level of tT3, fY4 and HR, it is superior to Metoprolol Tartrate combined with Propyhhiouracil, it is safe and reliable and has less adverse reactions, it is worthy of further promotion.