| 转换西罗莫司治疗肾移植后高胆红素血症的临床观察 |
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| 引用本文： | 敖建华,董隽,卢锦山,肖序仁. 转换西罗莫司治疗肾移植后高胆红素血症的临床观察[J]. 临床泌尿外科杂志, 2008, 23(12): 918-919 |
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| 作者姓名： | 敖建华 董隽 卢锦山 肖序仁 |
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| 作者单位： | 解放军总医院泌尿外科,北京,100853;解放军总医院泌尿外科,北京,100853;解放军总医院泌尿外科,北京,100853;解放军总医院泌尿外科,北京,100853 |
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| 摘 要： | 目的：对转换西罗莫司（SRL）并撤除钙调磷酸酶抑制剂（CNI）类药物对高胆红素血症影响及其安全性和可行性进行临床观察。方法：2006年2月～2007年11月对肾移植后伴有高胆红素血症患者37例转换SRL并撤除CNI类药物，观察转换后总胆红素（TB）水平变化、血清肌酐（Scr）变化和不良事件发生情况。结果：TB和直接胆红素（DB）由转换前的30．45μmol／L和10．10μmol／L下降至转换后的12．13μmol／L和3．7μmol／L（P〈0．01）。Scr和血尿酸（Ua）转换后较转换前均有较明显降低，肌酐清除率（Ccr）有所提高。移植肾和患者全部存活。不良事件主要为高脂血症。结论：转换SRI．治疗肾移植后高胆红素血症是有效和安全的。
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| 关 键 词： | 肾移植 西罗莫司 钙调磷酸酶抑制剂 高胆红素 |
Clinical observation of conversion from sirolimus therapy in renal transplantation recipients with hyperbilirubinemia |
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| AO Jian-hua,DONG Jun,LU Jin-shan,XIAO Xu-ren. Clinical observation of conversion from sirolimus therapy in renal transplantation recipients with hyperbilirubinemia[J]. Journal of Clinical Urology, 2008, 23(12): 918-919 |
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| Authors: | AO Jian-hua DONG Jun LU Jin-shan XIAO Xu-ren |
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| Affiliation: | 1 Department of Urology;the General Hospital of the PLA;Bejing;100853;China |
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| Abstract: | Objective:To evaluate the safety and efficacy of conversion from Calcineurin inhibitor(CNI)-based to Sirolimus(SRL)-based therapy in renal transplantation recipients with hyperbilirubinemia.Methods:37 renal transplant recipients with hyperbilirubinemia were enrolled.All the patients withdrew CNI and received sirolimusbased therapy.All the patients were followed up toobserve the changes of serum total bilirubin(TB),serum creatinine (Scr)and incidences of adverse events.Results:After conversion,mean TB level ... |
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| Keywords: | Renal transplantation Sirolimus Calcineurin inhibitor Hyperbilirubinemia |
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