| 亲水聚合物凝胶系统中药物控制释放两类特殊情况的数学模型 |
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| 引用本文： | 李凌冰,谭业邦.亲水聚合物凝胶系统中药物控制释放两类特殊情况的数学模型[J].生物医学工程学杂志,2003,20(1):17-21. |
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| 作者姓名： | 李凌冰 谭业邦 |
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| 作者单位： | 1. 山东大学,药学院,药剂教研室,济南,250012
2. 山东大学,化学院,济南,250100 |
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| 基金项目： | 国家自然科学基金资助项目 ( 2 990 40 0 3) |
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| 摘 要： | 对药物从亲水聚合物凝胶系统中释放的机理进行了研究，建立了药物释放的数学模型。同时考虑溶剂渗透引起材料松驰膨胀，在模型中引入了反映应力应变关系的弹性体方程，用摄动方法对方程进行了求解。同时利用溶胀界面数和扩散德伯拉数，对不同机理控制下的介质移动过程和药物释放过程，特别是材料松驰控制的药物释放过程进行了分析。
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| 关 键 词： | 亲水聚合物凝胶系统 药物控制释放 数学模型 黏弹应力 |
Two Sorts of Problems on Drug Controlled Release From Swellable Polymer |
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| Lingbing Li,Yebang Tan.Two Sorts of Problems on Drug Controlled Release From Swellable Polymer[J].Journal of Biomedical Engineering,2003,20(1):17-21. |
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| Authors: | Lingbing Li Yebang Tan |
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| Institution: | Department of Pharmaceutics, Shandong University, Jinan 250012. cn-lbli@263.net |
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| Abstract: | The mechanism of drug release from swellable polymer was studied .The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelastic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release, especially relax controlled mechanism. |
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| Keywords: | Swellable polymer Controlled release Model Viscoelastic stress |
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