Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia |
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| Authors: | Yan Wu Xi-Hong Ye Pei-Pei Guo San-Peng Xu Jie Wang Shi-Ying Yuan Shang-Long Yao You Shang |
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| Affiliation: | (1) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;(2) Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, 430022 Wuhan, China;(3) Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;(4) Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, 430022 Wuhan, China; |
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| Abstract: | Neuroprotective effect of lipoxin A4 methyl ester (LXA4 ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA4 ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA4 ME ameliorated neurological deficit, reduced infarct volume, attenuated histological damage, and decreased number of apoptotic neuron induced by ischemic insult. These neuroprotective effects of LXA4 ME were associated with inhibition of neutrophil infiltration, lipid peroxidation, and astrocyte activation. In addition, LXA4 ME also attenuated proinflammatory cytokines (TNF-α and IL-1β) production. These data suggest that LXA4 ME protects neuron against permanent cerebral ischemia by inhibiting inflammatory responses. |
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