Patients with severe liver cirrhosis followed up by L-[1-13C] phenylalanine breath test |
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Authors: | Ishii Yukimoto Suzuki Shigeru Kohno Tomohisa Aoki Masaru Goto Iori Kohno Tadashi Ito Asuka Asai Satoshi |
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Institution: | (1) Medical Research Center, Division of Genetic and Genomic Research, Nihon University School of Medicine, Tokyo, Japan;(2) Department of Surgery Division 3, Nihon University School of Medicine, Oyaguchi-Kami machi, Itabashi-ku, Tokyo, 173-8610, Japan;(3) Department of Internal Medicine Division 3, Nihon University School of Medicine, Tokyo, Japan;(4) Frontier Technology Research Institute, Tokyo Gas, Yokohama, Japan |
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Abstract: | Compared to healthy subjects, patients with severe liver cirrhosis (LC) are reported to show lower values in the L-1-13C] phenylalanine breath test (PBT). We performed this test several times during the clinical course in two patients with severe liver cirrhosis (LC). Patient 1 was a 67-year-old woman with non-B, non-C LC and hepatocellular carcinoma (HCC) in the lateral hepatic segment. Because the patient wanted to receive nonsurgical treatment for HCC, intraarterial administration of zinostatin stimalamer was performed. The patient was hospitalized four times before her death from liver failure on December 20, 2000. During her clinical course, PBT was performed four times. Values for both the rate of hepatic phenylalanine oxidation (%13C dose h–1) and %13C cumulative excretion gradually decreased during her clinical course. Patient 2 was a 57-year-old man with hepatitis C virus (HCV)-positive LC. He was hospitalized seven times between December 1998 and his death on May 24, 2001. During his clinical course, PBT was performed four times. Values for both %13C dose h–1 and %13C cumulative excretion decreased during his clinical course. We confirmed that PBT was useful for following the course of LC. |
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Keywords: | L-[1-13C] phenylalanine breath test liver cirrhosis |
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