甲状腺功能减退合并脑梗死的临床研究

目的研究甲状腺功能减退(甲减)、亚临床甲减对脑梗死的影响。方法选取甲减合并脑梗死、亚临床甲减合并脑梗死的患者84例,无甲状腺功能异常病史且入院化验甲状腺功能无异常的同期脑梗死患者88例作为对照组。测定脑梗死患者甲状腺功能、血糖、血脂、血同型半胱氨酸和纤维蛋白原并行颈部血管彩色超声检查。结果甲减组和亚临床甲减组在血糖、血同型半胱氨酸、胆固醇、低密度脂蛋白、甘油三酯等方面均高于对照组,差异有统计学意义;在有无颈动脉粥样硬化斑块、有无血管狭窄方面均存在差异;甲减组斑块发生率、颈动脉狭窄发生率均高于亚临床甲减组;亚临床甲减组在斑块发生率、颈动脉狭窄发生率均方面高于对照组。结论甲状腺功能减退、亚临床甲状腺功能减退可能是脑梗死的危险因素之一。

Clinical study of hypothyroidism with cerebral infarction

Objective To observe the effect of hypothyroidism and subclinical hypothyroidism on acute cerebral infarction. Methods 84 patients with hypothyroidism or subclinical hypothyroidism combined with acute cerebral infarction were recruited into this study. 88 acute cerebral infarction patients without hypothyroidism or subclinical hypothyroidism on the corresponding period were enrolled as the control group. Thyroid function,the level of blood glucose（ GLU）,total cholesterol（ TC）,low density lipoprotein-cholesterol（ LDL-C）,triglyceride（ TG）,homocysteine（HCY）,and fibrinogen（FIB）were tested,and cervical vascular ultrasonic examination was performed. Results Compared with the control group,patients in hypothyroidism group and subclinical hypothyroidism group were significantly higher at the level of blood GLU,HCY, TC,LDL-C and TG. And there are significant difference in the carotid atherosclerotic plaque and carotid artery stenosis among the groups. The incidence of plaque and carotid artery stenosis were higher in hypothyroidism group than that of subclinical hypothyroidism group,and higher than that in subclinical hypothyroidism group,higher than that in control group. Conclusion Hypothyroidism or subclinical hypothyroidism may be one of the risk factors of acute cerebral infarction.