缬沙坦氨氯地平复合制剂改善高血压患者血管弹性及颈动脉内膜中层厚度的作用

目的：观察缬沙坦氨氯地平复合制剂对高血压患者动脉弹性功能及颈动脉内膜中层厚度（C-IMT）的影响.方法：选取符合入选条件的80例高血压患者,随机分为2组,对照组（40例）口服氨氯地平（5 mg/d）、氢氯噻嗪（12.5 mg/d）,服药1年;治疗组（40例）口服缬沙坦氨氯地平片,每天1片（含缬沙坦80 mg,氨氯地平5 mg）,服药1年.测定颈动脉-股动脉脉搏波传导速度（CF-PWV）、大动脉和小动脉弹性指数（C1和C2） 、反射波增压指数和C-IMT,1年后复查上述指标.结果：经过1年治疗后,治疗组与对照组比较,CF-PWV减慢,C1和C2显著提高,反射波增压指数明显下降,C-IMT减少（P〈0.01）,而2组肱动脉血压治疗后均较治疗前明显下降（P〈0.01）,但2组差异均无统计学意义（P〉0.05）.结论：缬沙坦氨氯地平片在降压的同时可显著地降低了高血压患者C-IMT,明显改善高血压患者的动脉弹性.

The effect of valsartan and amlodipine tablets on the improvement of arterial elasticity and carotid intima-media thickness in patients with hypertension

Objective： To investigate the effects of valsartan and amlodipine tablets on the improvement of arterial elasticity and carotid intima-media thickness （C-IMT） in patients with hypertension. Methods： Eighty patients with hypertension were divided into the treatment group and control group （40 cases each group）. The treatment group and control group were treated with 80 mg/d of valsatan combined with 5 mg/d of amlodipine and 12.5 mg/d of hydrochlorothiazide combined with 5 mg/d of amlodipine by daily oral for 1 year, respectively. The carotid-femoral pulse wave velocity （CF-PWV）, large and small arterial elastic indexes （Cl and C2 ）, augumentation index and C-IMT in two groups were measured before and after treantment. Results：Compared with the control group after treatment, the CF-PWV was slow down, the indexes of C1 and C2 and pressurised reflected wave were increased, and the C-IMT were decreased in treatment group （ P 〈 0. 01 ）. The brachial artery blood pressure in 2 groups were decreased significantly after treatment（P 〈0.01 ）. The difference of which was not satistieally significant（ P 〉 0.05 ）. Conclusions： The valsartan combined with amlodipine can significantly reduce the hypertension and C-IMT, and improve the arterial elasticity in patients with hypertension.