| 上皮-间质转化在非小细胞肺癌侵袭与转移中作用的研究进展 |
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| 引用本文： | 贺金奇[综述],王晓红[审校].上皮-间质转化在非小细胞肺癌侵袭与转移中作用的研究进展[J].实用肿瘤学杂志,2013(6):559-562. |
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| 作者姓名： | 贺金奇[综述] 王晓红[审校] |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院内五科,哈尔滨150081 |
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| 摘 要： | 上皮-间质转化（Epithelial—mesenchymal transition，EMT）与恶性肿瘤的侵袭及转移有着密切的关系，是目前研究恶性肿瘤侵袭及转移的热点。有大量研究表明在多种恶性肿瘤如乳腺癌、卵巢癌和非小细胞肺癌的侵袭与转移过程中都有上皮-间质转化现象，并阐述上皮-间质转化的信号通路及其蛋白分子。本文对上皮-间质转化在非小细胞肺癌侵袭与转移的研究成果做一综述。
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| 关 键 词： | 非小细胞肺癌 侵袭与转移 上皮-间质转化 |
Research progress of epithelial - mesenchymal transition in Non - small cell lung cancer invasion and metastasis |
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| Institution: | HE Jinqi, WANG Xiaohong Department of Respiratory Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China |
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| Abstract: | Epithelial - mesenchymal transition is closely related with invasion and metastasis of malig- nant tumor and is focused on invasion and metastasis in malignant tumor in recent years. Many researches dermon- strate that epithelial - mesenchymal transition is involved in invasion and metastasis of several malignant tumors, such as breast cancer, ovary cancer and non - small cell lung cancer. The relevant signal pathways and molecular proteins are also studied. Research progress of epithelial - mesenchymal transition in non - small cell lung cancer for invasion and metastasis is reviewed in this article. |
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| Keywords: | Non- small cell lung cancer Invasion and metastasis Epithelial- mesenchymal transition |
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