乳腺癌新辅助化疗疗效的影响因素分析

目的探讨影响乳腺癌新辅助化疗(NAC)疗效的影响因素。方法 120例接受NAC的乳腺癌患者,采用免疫组化法确定雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体-2(HER-2)和Ki-67状态,并分析相关病历资料,Logistic回归分析患者达到病理完全缓解(p CR)的影响因素。结果 17例患者达到p CR,占14.2%。单因素分析结果显示,肿瘤大小、ER、PR和化疗方案为影响疗效达到p CR的相关因素。多元Logistic回归分析结果显示,肿瘤大小为影响疗效达到p CR的独立危险因素。结论乳腺癌NAC p CR与肿瘤大小、ER、PR和化疗方案等因素有关,其中肿瘤大小是其独立危险因素。

The influence factors of neoadjuvant chemotherapy for breast cancer

Objective To investigate the factors related to therapeutic effect of neoadjuvant chemotherapy（ NAC）for breast cancer. Methods 120 cases of breast cancer were included in the study who received NAC. Immunohistochemical method was used to determine ER, PR,HER-2 and Ki-67 states. Logistic regression analysis was used to analyze the related factors of pathological complete remission（ pCR）. Results There were 17 cases of pCR,accounted for 14. 2﹪. Single factor analysis showed,tumor size,ER,PR and chemotherapy regimen were the related factors of pCR. Multivariate logistic regression analysis showed tumor size was independent risk factor of pCR. Conclusion Tumor size,ER,PR and chemotherapy regimen were the related with pCR,while tumor size were the independent risk factors.