慢性肾功能衰竭患者血清三碘甲状腺原氨酸、甲状腺素和促甲状腺激素含量的变化及临床意义

目的：探讨慢性肾功能衰竭（ＣＲＦ）患者血清三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）和促甲状腺激素（ＴＳＨ）水平的变化及其临床意义。方法：采用放射免疫分析法测定６６例ＣＲＦ患者血清Ｔ３、Ｔ４和ＴＳＨ的含量，并与３０例正常人作对照分析。结果：ＣＲＦ患者失代偿期血清Ｔ３、Ｔ４水平随血尿素氮（ＢＵＮ）、肌酐（Ｃｒ）的升高而渐降低，与对照组比较均有显著性差异（Ｐ均＜０．０５）；ＴＳＨ与血ＢＵＮ和Ｃｒ的升高无关，治疗后Ｔ３、Ｔ４水平随病情好转而渐升高（Ｐ均＜０．０５）。结论：血清Ｔ３、Ｔ４水平可作为判断ＣＲＦ病情、观察药物疗效和预后的指标。

Changes of serum triiodothyronine,thyroxine and thyroid[-stimulating hormone levels in patients with chronic renal failure and its clinical significance

Objective:To investigate the changes of serum triiodothyronine (T 3),thyroxine(T 4) and thyroidstimulating hormone (TSH) levels in patients with chronic renal failure (CRF) and its clinical significance.Methods:Serum T 3,T 4 and TSH concentrations were detected by radioimmunoassay (RIA) in 66 cases with CRF,and compared to 30 health subjects.Results:Serum T 3 and T 4 levels of patients in compensative phase were decreased progressively accompanied by increasing of blood urea nitrogen (BUN) and creatinine (Cr) concentrations.They were obviously different compared to control group(all P <0 05).TSH level was not correlated with BUN and Cr concentrations.The concentrations of serum T 3 and T 4 were increased after treatment (all P <0 05).Conclusions:Serum T 3 and T 4 levels were useful indexes for judging the severity of CRF,observing the therapeutic efficacy and predicting the prognosis.