肺动脉灌注HTK液对肺动脉高压先心病患儿术后的肺保护作用

目的  研究体外循环期间肺动脉灌注HTK保护液对合并肺动脉高压的先心病患儿的肺保护作用。方法  将40例合并肺动脉高压的先心病患儿随机分为灌注组（体外循环+HTK液肺动脉灌注，n＝20）和对照组（体外循环, n＝20），进行心内畸形矫治，并于麻醉前、主动脉开放时、开放后6 、12 、24h 分别抽取动脉血样，测定血清中白介素-6（IL-6）和丙二醛（MDA）的浓度，并在相应的时间点抽取动脉血样行血气分析，计算各时间点的呼吸指数（RI）及氧和指数（OI）。结果  术后两组患儿血清中IL-6和MDA的浓度较术前明显升高，但灌注组明显低于对照组（P＜0.05）。灌注组患儿术后的RI及OI明显好于对照组（P＜0.05）。结论  体外循环期间行肺动脉灌注HTK液对合并肺动脉高压的先心病患儿有一定的肺保护作用。

Effect of pulmonary artery perfusion with HTK solution to congenital heart disease patients with pulmonary hypertension

Objective  To determine the effect of pulmonary perfusion with HTK solution on lung function during cardiopulmonary bypass (CPB) . Methods  Fourty congenital heart disease patients with pulmonary hypertension were randomly divided into two groups. During CPB, the study group were perfused with 4℃ HTK solution while the control group were not.  IL-6, MDA,RI  and OI were measured at different time points.  Results  The plasma levels of IL-6 and MDA in the study group were lower than those in the control group, and the difference was significant (P＜0.05）.  At each measuring point, OI of the study group was significantly higher than that of the control group (P<0.05).  RI of the study group was significantly lower than that of the control group (P<0.05)  after CPB. Conclusion  This study demonstrated that pulmonary artery perfusion with HTK solution can obviously reduce lung injury after cardiopulmonary bypass.