| 特非那丁对皮肤试验风团反应的抑制作用 |
| |
| 引用本文： | 张宏誉,张茸,岳凤敏,杨秀敏. 特非那丁对皮肤试验风团反应的抑制作用[J]. 中国新药与临床杂志, 1991, 0(5) |
| |
| 作者姓名： | 张宏誉 张茸 岳凤敏 杨秀敏 |
| |
| 作者单位： | 北京协和医院变态反应科，北京协和医院变态反应科，北京协和医院变态反应科，北京协和医院变态反应科 北京 100730，北京 100730，北京 100730，北京 100730 |
| |
| 摘 要： | 本试验的目的是客观评价特非那丁的疗效。共选择了42例典型的花粉症患者,用双盲法分为特非那丁组(20例)及安慰剂组(22例)。试验前进行皮肤试验终点滴定,在服特非那丁60mg,bid,或安慰剂3d后重复滴定。结果表明,特非那丁明显抑制了风团反应,平均终点稀释度从10~(-5.6)移至10~(-3.9)(P<0.01),而安慰剂组的风团大小及终点稀释度均无明显变化。
|
| 关 键 词： | 特非那定/治疗应用 皮肤试验 枯草热 组胺H_1受体阻滞剂 |
Inhibitory effect of terfenadine on the wheal reaction to skin test |
| |
| ZHANG Hong-Yu,ZHANG Rong,YUE Feng-Min,YANG Xiu-Min. Inhibitory effect of terfenadine on the wheal reaction to skin test[J]. Chinese Journal of New Drugs and Clinical Remedies, 1991, 0(5) |
| |
| Authors: | ZHANG Hong-Yu ZHANG Rong YUE Feng-Min YANG Xiu-Min |
| |
| Abstract: | The purpose of this study was to objectively evaluate the efficacy of terfenadine. Forty-two patients with typical pollinosis were chosen and divided into terfenadine group (n = 20) and placebo group (n = 22) by the double blind method. Prior to the trial, skin end point titration tests were performed. Following taking terfenadine 60mg bid (or placebo) for 3d the tests were repeated again. The results showed that the wheal reaction was inhibited by terfenadine, therefore, the end point dilution(EPD)changed from 10-5.6 to 10-3.9(P<0.01).There was no significant difference of wheal size and EPD in placebo group. |
| |
| Keywords: | terfenadine/therapautic use skin tests hay fever histamine H_1 receptor blockaders |
| 本文献已被 CNKI 等数据库收录！ |
|
