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| Tca8113和BcaCD885对口腔癌靶向隐形顺铂聚乳酸纳米粒的敏感性研究 | |
| 引用本文： | 杨凯,郑刚,温玉明.Tca8113和BcaCD885对口腔癌靶向隐形顺铂聚乳酸纳米粒的敏感性研究[J].口腔医学研究,2007,23(1):47-49. |
| 作者姓名： | 杨凯 郑刚 温玉明 |
| 作者单位： | 1. 重庆医科大学附属第一医院口腔颌面外科,重庆,400016 2. 重庆市中医研究院 3. 四川大学华西口腔医学院口腔颌面外科 |
| 基金项目： | 重庆市科委应用基础研究项目(渝科发计字〔2003〕43号)，重庆市卫生局科研项目(2001) |
| 摘 要： | 目的：观察口腔鳞癌细胞系（Tca8113和BcaCD885）对口腔癌靶向顺铂聚乳酸聚乙二醇纳米粒（CDDP—PLA—PEG—NP，或称隐形聚乳酸纳米）的敏感性，并与顺铂（CDDP）对Tca8113和BcaCD885的抗癌活性进行对比观察。方法：用四唑盐显色法（MTr法）检测CDDP—PLA—PEG—NP和CDDP在1～8d内8个时间点对Tca8113和BcaCD885的抗癌活性，计算出2种药物在8个时间点对2种癌细胞的抑癌率和药物的半数抑癌率浓度。结果：CDDP—PLA—PEG—NP和CDDP对Tca8113和BcaCD885均有强的杀伤作用，其杀伤效应均呈时间依赖性和剂量依赖性。结论：经改型后的CDDP—PLA—PEG—NP对口腔鳞癌细胞Tca8113和BcaCD885仍有强大的杀伤作用，为以后进一步的体内实验提供了依据。 |
| 关 键 词： | 口腔癌 聚乳酸 聚乙二醇 纳米粒 顺铂 |
| 文章编号： | 1671-7651(2007)01-0047-03 |
| 修稿时间： | 2006年4月24日 |
Chemosensitivity of Tca8113 and BcaCD885 Cell Lines to Cisplatin Loaded Polylactic Acid-polyethylene Glycol Nanoparticles for Targeting Oral Carcinoma |
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| YANG Kai,ZHENG Gang,WEN Yu-ming.Chemosensitivity of Tca8113 and BcaCD885 Cell Lines to Cisplatin Loaded Polylactic Acid-polyethylene Glycol Nanoparticles for Targeting Oral Carcinoma[J].Journal of Oral Science Research,2007,23(1):47-49. | |
| Authors: | YANG Kai ZHENG Gang WEN Yu-ming |
| Institution: | YANG Kai,ZHENG Gang,WEN Yu-ming.Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016 |
| Abstract: | Objective:To study chemosensitivity and anticancer activity of Cisplatin(CDDP) loaded polylactic acid-polyethylene glycol nanoparticles(CDDP-PLA-PEG-NP) against oral squamous carcinoma cell lines Tca8113(tongue carcinoma) and BcaCD885(buccal carcinoma).Methods: The chemosensitivity of Tca8113 and BcaCD885 to CDDP-PLA-PEG-NP and CDDP was tested using MTT assay.The suppressed cancer rate and 50% inhibition concentrations values(IC50) of two drugs against two cancer cell lines were counted for 1,2,3,4,5,6,7and 8 days at different concentrations.Results: Both CDDP-PLA-PEG-NP and CDDP showed high anticancer effects against Tca8113 and BcaCD855,the anticancer activity of two drugs was both dose and time dependent.Conclusion: CDDP within CDDP-PLA-PEG-NP remained its anticancer effects.And CDDP-PLA-PEG-NP showed higher than that of CDDP. |
| Keywords: | Oral carcinoma Polylactic acid Polyethylene glycol Nanoparticles Cisplatin |
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