| 非酒精性脂肪性肝炎的诊断和治疗进展 |
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| 引用本文： | 王引晗,解智博,杜顺达,毛一雷. 非酒精性脂肪性肝炎的诊断和治疗进展[J]. 腹部外科, 2021, 34(1): 18-21 |
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| 作者姓名： | 王引晗 解智博 杜顺达 毛一雷 |
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| 作者单位： | 中国医学科学院北京协和医学院基础医学院,北京100730;中国医学科学院北京协和医院肝脏外科,北京100730 |
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| 摘 要： | 非酒精性脂肪肝疾病(nonalcoholic fatty liver disease,NAFLD)以肝细胞中脂肪过多积累为标志,包括非酒精性脂肪肝(nonalcoholic fatty liver,NAFL)和非酒精性脂肪性肝炎(nonalcohol-ic steatohepatitis,NASH),其中NASH可能会...
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| 关 键 词： | 非酒精性脂肪肝疾病 非酒精性脂肪性肝炎 预测 诊断 治疗 |
Recent advances in the diagnosis and treatment of nonalcoholic steatohepatitis |
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| Wang Yinhan,Xie Zhibo,Du Shunda,Mao Yilei. Recent advances in the diagnosis and treatment of nonalcoholic steatohepatitis[J]. Journal of Abdominal Surgery, 2021, 34(1): 18-21 |
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| Authors: | Wang Yinhan Xie Zhibo Du Shunda Mao Yilei |
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| Affiliation: | (Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Liver Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China) |
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| Abstract: | Characterized with excessive accumulation of fat in liver cells,nonalcoholic fatty liver disease(NAFLD)is composed of nonalcoholic fatty liver(NAFL)and nonalcoholic steatohepatitis(NASH).As an inflammatory subtype of NAFLD,NASH may progress into cirrhosis and even hepatic tumor.However,there is currently no effective non-invasive diagnostic modality other than liver biopsy.And no approved drug is available for NASH.Thus it is imperative to seek suitable diagnostic biomarkers and effective therapeutic targets.With the progress of recent researches,scientists have acquired a deeper understanding of the pathogenic mechanism of NASH.Diagnostic models of multiple biomarkers have been put into trials.Many drug candidates against new targets have been evaluated for their effectiveness so that there is a brighter treatment prospect for NASH. |
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| Keywords: | Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Prediction Diagnosis Treatment |
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