辽阳地区HPV感染亚型分布及HPV疫苗接种意向调查

目的分析辽阳地区HPV感染亚型分布及HPV疫苗接种意向。方法以2017年11月至2019年12月在辽阳市中心医院妇产科体检进行HPV筛查的辽阳地区女性3612例作为研究对象,分析人群的HPV感染情况,比较不同年龄的HPV感染、多重HPV感染之间的差异,研究HPV疫苗接种意愿的影响因素。结果HPV感染阳性患者576例,感染率为15.95%。不同年龄的HPV感染情况之间的差异有统计学意义(χ2=9.261,P=0.000)。在低危型感染中,主要以HPV55、HPV61、HPV81为主,高危型感染中,主要以HPV16、HPV51、HPV66、HPV53为主。多因素分析中,年龄较低、家庭月收入较少、大学生在读以及所学专业或从事专业为非医药人群的HPV疫苗的意向显著降低。结论辽阳地区的高危型HPV主要为HPV16、HPV51、HPV66、HPV53,建议重点对年龄较小、家庭月收入较少、大学生在读以及所学专业或从事专业为非医药人群进行干预,以降低宫颈癌发病。

Distribution of HPV infection subtypes and HPV vaccination intention in Liaoyang

To analyze the distribution of HPV infection subtypes and HPV vaccination intention in Liaoyang area.Methods A total of 3612 women in Liaoyang area who underwent HPV screening at the Department of Gynecology and Obstetrics of Liaoyang Central Hospital from November 2017 to December 2019 were enrolled in this study.The HPV infection in the population was analyzed,and the differences in HPV infection and multiple HPV infection of people at different ages were compared.The influencing factors of vaccination willingness were analyzed.Results There were 576 patients with HPV infection,and the infection rate was 15.95%.The difference in HPV infection at different ages was statistically significant(χ2=9.261,P=0.000),and the difference in multiple HPV infections at different ages was statistically significant(P<0.05).Among low-risk infections,HPV55,HPV61,and HPV81 were the main subtypes,and among high-risk infections,HPV16,HPV51,HPV66,and HPV53 were the main subtypes.In the multivariate analysis,the HPV vaccination intention of people with lower age and lower monthly family income,college students and students with non-medical majors was significantly lower.Conclusion The high-risk types of HPV in Liaoyang area are mainly HPV16,HPV51,HPV66,and HPV53.It is recommended to focus on the intervention of young people,people with low family monthly income,college students and students with a non-medical major to reduce the incidence of cervical cancer.