穴位贴敷防治支气管哮喘不同皮肤反应对免疫球蛋白及嗜酸粒细胞的影响

目的:研究穴位贴敷防治支气管哮喘所出现的不同程度皮肤反应对血清免疫球蛋白(Ig E、Ig A、Ig M、Ig G)和嗜酸粒细胞(EOS)的影响。方法:对支气管哮喘患者于三伏天穴位贴敷,每伏贴敷一次,共3次。根据穴位贴敷后皮肤反应评分情况分为A、B、C、D 4组,A组43例,B组42例,C组39例,D组40例。检测治疗前、后各组患者血清Ig E、Ig A、Ig M、Ig G水平和血EOS计数。结果:除A组外,B、C、D 3组治疗前后各种血清免疫球蛋白及血EOS均有显著性差异(P<0.05或P<0.01)。治疗后与A组比较,B组各种血清免疫球蛋白及血EOS均无显著差异(P>0.05),C组除血EOS有显著差异外(P<0.05),各种免疫球蛋白均无显著差异(P>0.05),D组血清除Ig M及血EOS有显著差异外(P<0.05),Ig E、Ig A、Ig G均无显著差异(P>0.05)。结论:冬病夏治穴位贴敷有皮肤反应比无皮肤反应更能有效调节支气管哮喘患者的免疫功能。而出现皮肤反应后,随皮肤反应增强其对免疫功能的调节仅有轻度影响。因此适度皮肤反应即可有效调节免疫功能。

Influence of Different Skin Reactions on Immunoglobulin and Eosinophils by Acupoint Application for Preventing and Treating Bronchial Asthma

Objective ：To research the influence of different skin reactions on serum immunoglobulin （IgE, IgA,IgM, IgG） and eosinophils （EOS） by acupoint application for preventing and treating bronchial asthma. Methods：All of the bronchial asthma pa- tients were treated with acupoint application therapy in the dog - days, once every ten days, a total of three times. After treatment, according to the scores of skin reaction,164 cases were divided into group A （43 cases） ,B （42 cases） ,C （39 cases） and D （40 cases）. The levels of serum IgE,IgA, IgM, IgG and EOS were tested before and after treatment. Results ： In addition to group A, there were significant differences on the levels of IgE, IgA, IgM, IgG and EOS before and after treatment among groups B, C and D （P 〈0. 05 or P 〈0. 01 ）. After treatment,compared with group A,there were no significant differences on the levels of immuno-