Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties |
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Authors: | M Nishio K Tomatsu M Konishi K Tomita T Oki H Kawaguchi J Clardy |
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Affiliation: | Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan. |
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Abstract: | A complex of new antifungal antibiotics designated karnamicin was isolated from the cultured broth of Saccharothrix aerocolonigenes No. N806-4. Fifteen components have so far been isolated from the complex; the major component karnamicin B2 was identified by X-ray crystallography to be a novel molecule unrelated to known antibiotics. All components of karnamicin exhibited a rather broad spectrum of activity against fungi and yeasts with MICs ranging from 3.1 to 50 micrograms/ml. |
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