| 全反式维甲酸对脑胶质瘤细胞缝隙连接细胞间通讯功能的影响 |
| |
| 引用本文： | 洪涛 孙华 蒋丽萍 汪阳 卢明巍 何安慰. 全反式维甲酸对脑胶质瘤细胞缝隙连接细胞间通讯功能的影响[J]. 江西医学院学报, 2005, 45(1): 30-32 |
| |
| 作者姓名： | 洪涛 孙华 蒋丽萍 汪阳 卢明巍 何安慰 |
| |
| 作者单位： | [1]江西医学院第一附属医院脑外科，江西南昌330006 [2]江西医学院药理教研室，江西南昌330006 |
| |
| 基金项目： | 江西省科委资助课题,编号:E990502 |
| |
| 摘 要： | 目的 观察大鼠脑胶质瘤C6细胞缝隙连接细胞间通讯（GJIC)功能，并研究全反式维甲酸(ATRA)对C6细胞GJIC功能的影响。方法 (1)全反式维甲酸(ATRA)上调(36胶质瘤细胞GJIC功能；(2)划痕荷载染料传输实(SLDT)检测C6细胞ATRA处理前、后的细胞GJIC功能强弱；(3)光学显微镜观察ATRA处理前、后的细胞形态学变化。结果 (1)C6细胞GJIC功能低下；(2)ATRA上调C6胶质瘤细胞GJIC功能；(3)上调C6胶质瘤细胞GJIC功能后细胞增殖受到抑制。结论 (1)ATRA是C6细胞GJIC功能上调剂之一；(2)GJIC功能强弱可影响肿瘤细胞增殖。
|
| 关 键 词： | 胶质瘤 缝隙连接细胞间通讯 全反式维甲酸 |
| 文章编号： | 1000-2294(2005)01-0030-03 |
| 修稿时间： | 2004-08-02 |
Effect of All-Trans Retinoic Acid on the Gap Junctional Intercellular Communication of C6 Cells |
| |
| HONG Tao ,SUN Hua ,JIANG Li-ping ,WANG Yang ,LU Ming-wei ,HE An-wei. Effect of All-Trans Retinoic Acid on the Gap Junctional Intercellular Communication of C6 Cells[J]. Acta Academiae Medicinae Jiangxi, 2005, 45(1): 30-32 |
| |
| Authors: | HONG Tao SUN Hua JIANG Li-ping WANG Yang LU Ming-wei HE An-wei |
| |
| Affiliation: | HONG Tao 1,SUN Hua 1,JIANG Li-ping 2,WANG Yang 1,LU Ming-wei 1,HE An-wei 1 |
| |
| Abstract: | Objective To study the gap junctional intercellular communication(GJIC) of the C6 cells and evalute the effect of all-trans retinoic acid(ATRA) on the GJIC of the cells.Methods (1)ATRA was used to upregulate the GJIC of the C6 cells;(2)The GJIC of C6 cells was evaluated with SLDT(scrape loading dye transfer);(3)Microscope was used to study the morphological changes of C6 cells before and after treated by ATRA.Results (1)The GJIC of the C6 cells was poor;(2)ATRA upregulated the GJIC of the C6 cells;(3)Growth retardation was observed after the GJIC of C6 cells had been upregulated by ATRA.Conclusion (1)ATRA is one of the upregulators of the GJIC of C6 cells;(2)GJIC has influence upon tumor growth. |
| |
| Keywords: | glioma gap junctional intercellular communication all-trans retinoic acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
