T helper cells. |
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Authors: | R Noelle E C Snow |
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Institution: | Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756. |
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Abstract: | B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation. |
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