| 疱疹类病毒与喉良性及恶性上皮病变的关系 |
| |
| 引用本文： | 林昶,姜泗长,杨伟炎,韩东一,易自翔.疱疹类病毒与喉良性及恶性上皮病变的关系[J].临床耳鼻咽喉头颈外科杂志,2001,15(3):122-124. |
| |
| 作者姓名： | 林昶 姜泗长 杨伟炎 韩东一 易自翔 |
| |
| 作者单位： | 1. 福建医科大学附属第一医院耳鼻咽喉科
2. 解放军总医院耳鼻咽喉科 |
| |
| 摘 要： | 目的 :探讨疱疹类病毒在喉良恶性上皮病变中的作用。方法 :采用通用引物多聚酶链反应 (PCR)及原位多聚酶链反应 (PCR- ISH)对 12 8例喉良恶性病变进行了检测。结果 :PCR检测 12 8例标本 ,10例检出单纯庖疹病毒 1型 (HSV - 1) ,其中喉癌 3例 ,原位癌 1例 ,息肉 4例 ,角化症 2例 ,未检出爱泼斯坦病毒 (EBV)及巨细胞病毒 (CMV )。 10例阳性标本用 PCR- ISH定位检测 ,除 1例鳞癌和 1例原位癌阴性外 ,其余 8例均阳性 ,良性病变从基底层到浅层细胞核均阳性 ,癌症中则散在阳性 ,1例腺体细胞核也呈阳性。结论 :EBV及 CMV与喉病变无关 ;大部分喉良恶性上皮病变与 HSV- 1无关 ,但在少数患者 ,HSV - 1可能起诱发作用。
|
| 关 键 词： | 喉肿瘤 疱疹病毒 多聚酶链反应 |
| 文章编号： | 1001-1781(2001)03-0122-03 |
| 修稿时间： | 2000年6月15日 |
Herpesviridae and laryngeal neoplasia |
| |
| LIN Chang,JIANG Sichang,YANG Weiyan,Han Dongyi,YI Zixiang.Herpesviridae and laryngeal neoplasia[J].Journal of Clinical Otorhinolaryngology,2001,15(3):122-124. |
| |
| Authors: | LIN Chang JIANG Sichang YANG Weiyan Han Dongyi YI Zixiang |
| |
| Institution: | Department of Otolaryngology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005. |
| |
| Abstract: | Objective:To investigate the relationship between herpesviridae and malignant or benign laryngeal diseases.Method:128 paraffin embedded laryngeal squamous cell carcinoma and laryngeal epithelium hyperplastic lesions were detected by polymerase chain reaction (PCR) and PCR ISH for herpesviridae. Result:HSV 1 was detected in 10 cases by PCR,among them 3 were laryngeal squamous cell carcinoma (LSCC),1 was carcinoma in situ(CIS),4 were laryngeal polyps and 2 were laryngeal keratosis. Except 1 LSCC and 1 CIS, 8 of 10 cases were positive while detected by PCR ISH. In benign diseases, signals were shown from basal layer to superficial cell; in malignant lesions, the signals were scattered in the diseases.Conclusion:Most of laryngeal diseases were not related to herpesviridae, but HSV 1 may acts as initiator in the development of a few cases. |
| |
| Keywords: | Laryngeal neoplasm Herpes simplex virus 1 Polymerase chain reaction |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
