血清尿酸在冠心病患者中的变化及意义

目的 探讨血清尿酸水平与冠心病的关系.方法 经冠状动脉造影确诊的冠心病患者(冠心病组)95例和非冠心病患者(对照组)72例,冠心病组又分为单支病变亚组(40例)、双支病变亚组(32例)和三支病变亚组(23例),均测定血清尿酸水平.结果 冠心病组血清尿酸水平显著高于对照组(P＜0.01),双支病变亚组和三支病变亚组血清尿酸水平均显著高于单支病变亚组(P＜0.05;P＜0.01).结论 血清尿酸水平与冠心病密切相关,且随冠心病病情严重程度而增加,高尿酸血症是冠心病的一个危险因素.

Changes of Serum Uric Acid in Patients with Coronary Heart Disease and its Significance

Objective To investigate the correlation between serum uric acid (SUA) and coronary heart disease (CHD) . Methods 95 patients with CHD proved by angiography and 72 control subjects without CHD were included in this study.The group of CHD was divided into three subgroups of single-branch, double-branch and three-branch according to the scope of pathological changes. SUA levels were measured. Results SUA levels in CHD group were significantly higher than those in control group(P<0.01). SUA levels in double-branch subgroup and three-branch subgroup were obviously higher than those in single-branch subgroup(P<0.05,P<0.01). Conclusion The SUA levels have a close ralationship with CHD. The SUA levels increase along with the severity of cornary heart disease. Hyperuricemia is one of risk factors in CHD .