| 白花蛇舌草抗炎、抗肿瘤作用研究进展 |
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| 引用本文： | 王信, 马传江, 杨培民, 曹广尚, 郭功玲, 李健, 辛义周. 白花蛇舌草抗炎、抗肿瘤作用研究进展[J]. 中国现代应用药学, 2020, 37(19): 2420-2427. DOI: 10.13748/j.cnki.issn1007-7693.2020.19.022 |
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| 作者姓名： | 王信 马传江 杨培民 曹广尚 郭功玲 李健 辛义周 |
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| 作者单位： | 1.山东中医药大学附属医院, 国家中医药管理局中药制剂三级实验室, 济南 250011 |
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| 基金项目： | 国家自然科学基金项目（面上项目） |
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| 摘 要： | 慢性炎症与肿瘤的发生、发展、侵袭、转移等密切相关，清热解毒中药白花蛇舌草兼具抗炎、抗肿瘤作用，在临床上常用于各种炎症、肿瘤的预防与治疗。白花蛇舌草抗炎机制研究主要涉及NF-kB、MAPK、5-LOX等信号通路，抗肿瘤研究主要为抗肠癌、抗肺癌、抗肝癌、抗乳腺癌、抗胃癌等，机制涉及PI3K/AKT、TGF-β/Smad、MAPK、STAT3等信号通路，并可能通过NF-kB、MAPK、VEGF等途径在“炎-癌”转化过程中发挥重要作用。本文综述白花蛇舌草抗炎、抗肿瘤及干预“炎-癌”转化作用，为其进一步研究提供参考。
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| 关 键 词： | 炎-癌转化 白花蛇舌草 抗炎 抗肿瘤 |
| 收稿时间： | 2019-09-09 |
| 修稿时间： | 2019-12-17 |
Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd. |
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| WANG Xin, MA Chuanjiang, YANG Peimin, CAO Guangshang, GUO Gongling, LI Jian, XIN Yizhou. Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd.[J]. Chinese Journal of Modern Applied Pharmacy, 2020, 37(19): 2420-2427. DOI: 10.13748/j.cnki.issn1007-7693.2020.19.022 |
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| Authors: | WANG Xin MA Chuanjiang YANG Peimin CAO Guangshang GUO Gongling LI Jian XIN Yizhou |
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| Affiliation: | 1.Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Grade Three Laboratory of Traditional Chinese Medicine Preparation of State Administration of Traditional Chinese Medicine, Jinan 250011, China |
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| Abstract: | Chronic inflammation is closely related to the occurrence, development, invasion and metastasis of tumors. Hedyotis diffusa Willd. has both anti-inflammatory and anti-tumor effects and is often used to prevent and treat various kinds of inflammation and tumors. The anti-inflammatory mechanism of Hedyotis diffusa Willd. is related to NF-κB, MAPK, 5-LOX and other signaling pathways and the anti-tumor effects include anti-colon cancer, anti-lung cancer, anti-liver cancer, anti-breast cancer, anti-gastric cancer, etc and anti-tumor mechanisms include signaling pathways such as PI3K/AKT, TGF-/Smad, MAPK, STAT3. Hedyotis diffusa Willd. plays an important role in the process of |
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| Keywords: | inflammation-cancer transformation Hedyotis diffusa Willd. anti-inflammatory anti-tumor |
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