| 液液分配色谱及其与液相色谱联用分离天然花色苷的研究进展 |
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| 引用本文： | 孙恒勉,鲍虹蕾,童胜强.液液分配色谱及其与液相色谱联用分离天然花色苷的研究进展[J].中草药,2020,51(22):5856-5863. |
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| 作者姓名： | 孙恒勉 鲍虹蕾 童胜强 |
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| 作者单位： | 浙江工业大学药学院, 浙江 杭州 310014 |
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| 基金项目： | 国家自然科学基金资助项目（21978266） |
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| 摘 要： | 液液分配色谱（liquid-liquid partition chromatography，LLC）是一种连续高效的分配色谱技术，如今已广泛应用于天然产物领域。天然花色苷是一种黄酮类天然色素，具有多种生理活性。花色苷极不稳定，LLC因其具有操作条件温和、可避免样品不可逆吸附等特点目前已广泛应用于天然花色苷的制备性分离。综述了2010—2019年LLC及其与液相色谱联用（liquid-liquid partition chromatography-liquid chromatography，LLC-LC）分离纯化天然花色苷的研究进展。
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| 关 键 词： | 液液分配色谱 液液分配色谱-液相色谱联用 花色苷 分离纯化 二维色谱 |
| 收稿时间： | 2020/3/1 0:00:00 |
Research progress on separation of natural anthocyanin by liquid-liquid partition chromatography and combination with liquid chromatography |
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| SUN Heng-mian,BAO Hong-lei,TONG Sheng-qiang.Research progress on separation of natural anthocyanin by liquid-liquid partition chromatography and combination with liquid chromatography[J].Chinese Traditional and Herbal Drugs,2020,51(22):5856-5863. |
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| Authors: | SUN Heng-mian BAO Hong-lei TONG Sheng-qiang |
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| Institution: | College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China |
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| Abstract: | Liquid-liquid partition chromatography (LLC) is a continuous and efficient chromatography technique now widely used in the field of natural products. Natural anthocyanin is a flavonoid natural pigment with many physiological activities. Anthocyanin is very unstable and LLC has been widely used in the separation of natural anthocyanin because of its mild operating conditions and the avoidance of irreversible adsorption of samples. The research progress on separation of natural anthocyanin by LLC and combination with liquid chromatography from 2010 to 2019 is reviewed in this paper. |
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| Keywords: | LLC LLC-LC anthocyanin purification two-dimensional chromatography |
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