视网膜静脉阻塞视盘区量化OCTA的临床研究

目的：探讨量化光学相干断层扫描血管成像(OCTA)在视网膜静脉阻塞(RVO)患者中的临床应用价值。

方法：前瞻性病例资料研究。选取2018-01/2019-12在潍坊医学院附属医院眼科中心检查确诊的RVO患者40例40眼，选取年龄、性别与RVO患者相匹配的健康体检者40例42眼作为正常对照组。采用OCTA测量两组受检者视盘区血流密度，并评估各参数的差异。

结果：RVO患者患眼整个图像血管(t=-2.953，P<0.001)、视盘周血管(t=-3.533，P=0.001)、整个图像毛细血管(t=-3.192，P=0.003)、视盘周毛细血管(t=-3.930，P<0.001)、下方鼻侧(t=-2.854，P=0.007)、下方颞侧(t=-3.696，P=0.001)、颞下(t=-3.418，P=0.002)、颞上(t=-3.170，P=0.003)、上方颞侧(t=-3.082，P=0.004)、上方鼻侧(t=-2.912，P=0.006)区域内的血流密度均较对侧眼明显下降。RVO患者患眼各个区域内的血流密度均较正常对照组明显下降(P<0.05)。RVO患者对侧眼整个图像血管(t=-2.213，P=0.032)、视盘内血管(t=-2.270，P=0.028)、整个图像毛细血管(t=-2.192，P=0.033)、视盘内毛细血管(t=-2.449，P=0.018)、颞上(t=-2.147，P=0.037)区域内的血流密度均较正常对照组明显下降。

结论：量化OCTA揭示了RVO患者视盘区血流密度下降，提示视盘区量化OCTA对于RVO病情的评估及对侧眼的预防具有临床应用价值。

Clinical study of retinal vein occlusion papillary area with quantified OCTA

AIM: To explore the clinical application value of optical coherence tomography angiography(OCTA)in patients with retinal vein occlusion(RVO).

METHODS:Retrospective case study. From January 2018 to December 2019, 40 cases with 40 eyes of RVO patients diagnosed in the Eye Center of the Affiliated Hospital of Weifang Medical University were selected, and 40 healthy subjects with 42 eyes matching the age and gender of RVO patients were selected as normal control group. OCTA was used to measure the papillary vessel density of the two groups, differences in parameters were evaluated.

RESULTS: The blood vessel density in the areas of the whole image blood vessels(t=-2.953, P<0.001), the peripapillary blood vessels(t=-3.533, P=0.001), the whole image capillaries(t=-3.192, P=0.003), the peripapillary capillaries(t=-3.930, P<0.001), inferior nasal(t=-2.854, P=0.007), inferior tempo(t=-3.696, P=0.001), tempo inferior(t=-3.418, P=0.002), tempo superior(t=-3.170, P=0.003), superior tempo(t=-3.082, P=0.004)and superior nasal(t=-2.912, P=0.006)in the eyes of patients with RVO was significantly lower than that of the fellow eyes of patients with RVO. The blood vessel flow density in the all areas of in the eyes of patients with RVO was significantly lower than that of the normal control group. The blood vessel density in the areas of the whole image blood vessels(t=-2.213, P=0.032), the blood vessels inside disc(t=-2.270, P=0.028), the whole image capillaries(t=-2.192, P=0.033), capillaries inside disc(t=-2.449, P=0.018)and tempo superior(t=-2.147, P=0.037)in the fellow eyes of patients with RVO was significantly lower than that of the normal control group.

CONCLUSION:Quantitative OCTA reveals a decrease in the vessel density of papillary area of patients with retinal vein occlusion, suggesting that papillary area with quantified OCTA has clinicalapplication value for the assessment of the severity and prevention of the fellow eyes with retinal vein occlusion disease.