西地那非联合比索洛尔治疗顽固性高血压的疗效分析

目的 研究西地那非联合比索洛尔治疗顽固性高血压的临床疗效。方法 选择2016年1月-2019年1月四川省甘孜藏族自治州卫生学校附属医院治疗的150例顽固性高血压患者作为研究对象，采用抽签法将患者随机分为对照组和观察组，每组各75例。对照组口服富马酸比索洛尔片，5 mg/次，1次/d。观察组在对照组的基础上口服枸橼酸西地那非片，50 mg/次，1次/d。两组均连续服药8周。观察两组患者的血压和症状疗效，同时比较两组治疗前后的24 h动态血压。结果 治疗后，观察组的血压控制总有效率为85.33%，明显高于对照组的65.33/%（P<0.05）。治疗后，观察组的症状改善总有效率为94.67%，明显高于对照组的72.00%（P<0.05）。治疗后，两组患者日间舒张压（d DBP）、日间收缩压（d SBP）、24 h舒张压（24 h DBP）、24 h收缩压（24 h SBP）、夜间舒张压（n DBP）和夜间收缩压（n SBP）均显著降低（P<0.05）；且观察组的24 h动态血压水平明显低于对照组（P<0.05）。结论 西地那非联合比索洛尔对顽固性高血压患者具有较好的疗效，值得应用推广。

Clinical analysis of sildenafil combined with bisoprolol in treatment of refractory hypertension

Objective To study the effect of sildenafil combined with bisoprolol in treatment of refractory hypertension. Methods 150 patients with intractable hypertension in Affiliated Hospital of Health School, Ganzi Tibetan Autonomous Prefecture, Sichuan Province from January 2016 to January 2019 were selected as study subjects, and randomly divided into control group and observation group by lottery, with 75 patients in each group. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, 5 mg/time,once daily. Patients in the observation group were po administered with Sildenafil Citrate Tablets on the basis of control group, 50 mg/time, once daily. Patients in two group were treated for 8 weeks. The blood pressure and symptom efficacy in two groups were observed, and the dynamic blood pressure at 24 h before and after treatment was compared between two groups. Results After treatment, the total effective rate of blood pressure control in the observation group was 85.33%, which was significantly higher than 65.33/% in the control group (P<0.05). After treatment, the total effective rate of symptom improvement in the observation group was 94.67%, which was significantly higher than 72.00% in the control group (P<0.05). After treatment, D DBP, D SBP, 24 h DBP, 24 h SBP, n DBP and n SBP were significantly decreased in two groups (P<0.05). Moreover, the 24-hour ambulate blood pressure level of the observation group was significantly lower than those of the control group (P<0.05). Conclusion Sildenafil combined with bisoprolol has a good effect on patients with refractory hypertension and is worthy of application and promotion.