湿润烧伤膏治疗乳腺癌改良根治术后切口感染疗效观察

目的对比观察湿润烧伤膏治疗乳腺癌改良根治术后切口感染的临床疗效。方法选取2016年8月至2019年8月安阳市肿瘤医院收治的65例乳腺癌改良根治术后切口感染患者作为研究对象,根据不同治疗方法将其分为研究组(33例)与对照组(32例),其中研究组患者采用湿润烧伤膏治疗局部感染切口,对照组患者采用康复新液治疗局部感染切口,对比两组患者切口愈合时间以及治疗第3、7、14天时血清降钙素原(PCT)、C-反应蛋白(CRP)与白细胞介素-6(IL-6)的变化情况。结果治疗第3、7、14天,研究组患者血清PCT、CRP、IL-6水平均明显低于对照组(PCT:t=2.322、3.389、2.285,P=0.024、0.001、026;CRP:t=2.145、2.290、2.245,P=0.036、0.025、0.028;IL-6:t=2.382、3.460、2.846,P=0.020、0.001、0.006);最终,两组患者感染切口均完全愈合,其中研究组患者的切口愈合时间明显短于对照组(t=2.930,P=0.005)。结论湿润烧伤膏可有效抑制乳腺癌改良根治术后切口感染,促进切口愈合,疗效显著,临床应用价值较高。

Curative Effect of MEBO in the Treatment of Incision Infection after the Breast Cancer Modified Radical Mastectomy

Objective: To observe the clinical efficacy of MEBO in treating incision infection after the breast cancer modified radical mastectomy. Methods: Sixty-five patients with incision infection, who underwent breast cancer modified radical mastectomy in Anyang Cancer Hospital between August 2016 and August 2019, were selected as the study subjects to be divided into a study group (33 patients) and a control group (32 patients) based on different treatments. The incision infection of patients in the study group was treated with MEBO while the incision infection of patients in the control group was treated with Kangfuxin Solution. The incision healing time, and the changes of serum procalcitonin (PCT), C-reactive protein (CRP) and leukocyte interleukin-6 (IL-6) on day 3, 7 and 14 of treatment were compared between the two groups. Results: On day 3, 7 and 14 of treatment, the levels of serum PCT, CRP and IL-6 of patients in the study group were all significantly lower than that in the control group (PCT: t=2.322, 3.389 and 2.285, P=0.024, 0.001 and 0.026; CRP: t=2.145, 2.290 and 2.245, P=0.036, 0.025 and 0.028; IL-6: t=2.382, 3.460 and 2.846, P=0.020, 0.001 and 0.006). In the end, the incisions of all patients in the two groups were completely healed, while the healing time in the study group was obviously shorter than that in the control group (t=2.930, P=0.005). Conclusion: MEBO can effectively inhibit the incision infection after breast cancer modified radical mastectomy, promote incision healing, presenting a high value of clinical application.