妊娠期糖尿病患者眼表相关指标的临床分析

目的：应用Keratogragh 5M眼表分析仪对比妊娠期糖尿病孕妇与正常孕妇眼表相关指标。

方法：选择妊娠期糖尿病患者45例45眼及正常孕妇48例48眼作为研究对象。所有对象完成眼表疾病指数(OSDI)问卷调查对眼表进行评分，应用Keratogragh 5M测量泪河高度(TMH)、非侵入性平均泪膜破裂时间(NIKBUTav)、眼红指数、睑板腺缺失评分。得出结果后对两组各项指标进行比较。

结果：妊娠期糖尿病组及正常孕妇组的OSDI、TMH、NIKBUTav、眼红指数及睑板腺缺失评分均无差异(P>0.05)。其中OSDI分别为8.02±4.25、7.50±4.28分(P=0.557)，TMH值分别为0.22±0.05、0.20±0.04mm(P=0.158)，NIKBUTav值分别为8.01±2.15、8.02±1.53s(P=0.971)。

结论：妊娠期糖尿病组与正常孕妇组眼表各项指标差异均无统计学意义，妊娠期糖尿病对眼表相关指标没有明显的影响，可能与血糖控制良好有关。

Ocular surface analysis in gestational diabetes mellitus

AIM: To evaluate ocular surface functions in pregnant women with gestational diabetes mellitus(GDM)using Keratogragh 5M.

METHODS: Pregnant women with GDM and normal pregnant women were enrolled. All subjects were asked to answer ocular surface disease index(OSDI)questionnaire survey, and then underwent ophthalmic examination including tear meniscus height(TMH), average noninvasive Keratograph tear film break-up time(NIKBUTav), ocular redness analysis, and meibomial gland analysis.

RESULTS: There were no statistically significant differences in OSDI, TMH, NIKBUTav, eye redness analysis and meibomial gland analysis between the GDM group and the normal pregnant group(P>0.05). The OSDI scores were 8.02±4.25 and 7.50±4.28(P=0.557), TMH values were 0.22±0.05 and 0.20±0.04mm(P=0.158), NIKBUTav values were 8.01±2.15s and 8.02±1.53s(P=0.971).

CONCLUSION: There was no statistically significant difference between the GDM group and the normal pregnant group in ocular surface indexes. GDM had no negative effects on ocular surface, which may be related to good controlling of the blood glucose.