小儿生血糖浆联合蛋白琥珀酸铁口服溶液治疗小儿缺铁性贫血的疗效观察

目的 从药效学角度探讨甘草-大戟配伍禁忌的机制。方法 30只SD大鼠按体质量随机分成6组，每组5只，即大戟单煎液组、甘草单煎液组、甘草-大戟（1：1、2：1、3：1）合煎液组和对照组，分别ig等体积大戟单煎液（0.24 g/kg）、甘草单煎液（0.72 g/kg）、甘草-大戟1：1合煎液（甘草0.24 g/kg、大戟0.24 g/kg）、甘草-大戟2：1合煎液（甘草0.48 g/kg、大戟0.24 g/kg）、甘草-大戟3：1合煎液（甘草0.72 g/kg、大戟0.24 g/kg）和等体积生理盐水，大戟、甘草单煎液剂量设置参考《中国药典》规定的人口服剂量，根据人和大鼠体表面积比例进行换算。观察大鼠的排尿量、尿液中总蛋白含量、排便量、小肠推进率，考察甘草对大戟峻下逐水作用的影响。结果 与大戟单煎液组比较，甘草-大戟合煎液组大鼠的排尿量和排便量减少，小肠推进率降低，尿液中总蛋白浓度升高，其中，甘草-大戟（1：1、2：1、3：1）合煎液组大鼠的排便量均显著减少（P<0.05、0.01），甘草-大戟（1：1、3：1）合煎液组大鼠的排尿量显著减少（P<0.01），甘草-大戟（2：1、3：1）合煎液组大鼠的小肠推进率显著降低（P<0.01），甘草-大戟（2：1、3：1）合煎液组大鼠尿液中总蛋白浓度显著升高（P<0.01）。结论 甘草与大戟配伍可明显拮抗大戟的利尿和泻下作用，影响大戟的峻下逐水功效。

Clinical observation of Xiaoer Shengxue Syrup combined with Iron Proteinsuccinylate Oral Solution in treatment of iron deficiency anemia in children

Objective To investigate the pharmacodynamic incompatibility of Glycyrrhizae Radix with Euphorbiae Pekinensis Radix. Methods Tatolly thirty SD rats were randomly divided into six groups according to body weight, with five rats in each group, namely, Euphorbiae Pekinensis single decoction group, Radix Glycyrrhizae single decoction group, Radix Glycyrrhizae-Euphorbiae Pekinensis (1:1, 2:1, 3:1) combined decoction group, and control group. The same volume of Euphorbiae Pekinensis single decoction (0.24 g/kg), Radix Glycyrrhizae single decoction (0.72 g/kg), Radix Glycyrrhizae-Euphorbiae Pekinensis (1:1) combined decoction (0.24 g/kg + 0.24 g/kg), Radix Glycyrrhizae-Euphorbiae Pekinensis (2:1) combined decoction (0.48 g/kg + 0.24 g/kg),Radix Glycyrrhizae-Euphorbiae Pekinensis (3:1) combined decoction (0.72 g/kg + 0.24 g/kg), and normal saline were ig to relative group. In order to investigate the influence of Radix Glycyrrhizae on the drastic diuretic effect of Euphorbiae Pekinensis, observed the urine output, total protein content in the urine, defecation amount and small intestinal propulsive rate of rats. Results Compared with the Euphorbiae Pekinensis single decoction group, all of the Radix Glycyrrhizae-Euphorbiae Pekinensis (1:1, 2:1, 3:1) groups showed less urine output and defecation amount, lower intestinal propulsive rate and higher urinary protein concentration. Compared with the Euphorbiae Pekinensis single decoction group, All of the Radix Glycyrrhizae-Euphorbiae Pekinensis (1:1, 2:1, 3:1) groups had significantly less defecation amount (P<0.05 and 0.01), a part of the Radix Glycyrrhizae -Euphorbiae Pekinensis (1:1, 3:1) groups had significantly less urine output (P<0.01), a part of the Radix Glycyrrhizae-Euphorbiae Pekinensis (2:1, 3:1) groups showed significantly lower intestinal propulsive rate (P<0.01), and a part of the Radix Glycyrrhizae-Euphorbiae Pekinensis (2:1, 3:1) groups exhibited significantly higher urinary protein concentration (P<0.01). Conclusion The concomitant using Radix Glycyrrhizae can obviously suppress the diuretic and purgative effects of Euphorbiae Pekinensis, and influence its drastic diuretic efficacy.