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Protective effects of glutamine preconditioning on ischemia-reperfusion injury in rats |
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| Authors: | Wan-Xing Zhang Li-Fang Zhou Lei Zhang Lei Bao Chun-ChengWang Hui-Yan Meng WenYin |
| Affiliation: | Wan-Xing Zhang,Li-Fang Zhou,Lei Zhang,Lei Bao,Chun-ChengWang,Hui-Yan Meng and WenYin Department of Hepatobiliary Surgery,and Department of Pharmacy,Hebei Provincial General Hospital,Shijiazhuang 050051,China |
| Abstract: | BACKGROUND:Hepatic ischemia-reperfusion injury is a common phenomenon in hepatic surgical procedures and can result in further severe damage.This study aimed to investigate the protective effects of glutamine preconditioning on hepatic ischemia-reperfusion injury in rats and its dose-dependency. METHODS:Thirty-two healthy male Wistar rats were randomly divided into four groups(n=8 per group).One group received 0.9%NaCl(control)and the other three received glutamine(Gln groups)4 hours before ischemia.The Gln... |
| Keywords: | ischemia-reperfusion injury liver glutamine Na /K ATPase calcium overload |
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