| 脑缺血再灌注后脑组织c-fos基因表达与丹参的影响 |
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| 引用本文： | 吴卫平,李振洲,匡培根.脑缺血再灌注后脑组织c-fos基因表达与丹参的影响[J].中国神经免疫学和神经病学杂志,1995,2(1):1-3,T001. |
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| 作者姓名： | 吴卫平 李振洲 匡培根 |
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| 作者单位： | 北京解放军总医院神经内科神经介质实验室 |
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| 摘 要： | 采用线栓法制成大鼠大脑中动脉缺血再灌注模型，用地高辛精标记ｃ－ｆｏｓ探针进行原位杂交。结果示缺血再灌注鼠栓塞侧皮层及海马ｃ－ｆｏｓ基因表达显著增多，图像分析灰阶值为１１８．６±５．１，对侧为１５９．６±３．１（Ｐ＜０．００１）。丹参组栓塞侧皮层及海马ｃ－ｆｏｓ基因表达亦增多，灰阶为１３５．００±２．０５，对侧为１６７．００±２．００（Ｐ＜０．００１）。丹参组与缺血再灌注组比较，栓塞侧丹参组ｃ－ｆｏｓ基因表达显著低于缺血再灌组（Ｐ＜０．０５），而两组栓塞对侧比较无显著差异。本实验表明，脑缺血再灌注后脑组织ｃ－ｆｏｓ基因表达显著增多，丹参能部分抑制缺血后ｃ－ｆｏｓ基因的表达，这可能是其治疗缺血性脑血管病的机理之一。
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| 关 键 词： | c-fos基因 表达 丹参 栓塞 后脑组织 脑缺血再灌注 皮层 探针 |
Effect of Radix Salviae Miltiorrhizae(RSM)on c-fos Gene Expression in Rat Brains after Cerebral Ischemia and Reperfusion |
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| Wu Weiping,Li Zhenzhou,Kuang Peigen.Effect of Radix Salviae Miltiorrhizae(RSM)on c-fos Gene Expression in Rat Brains after Cerebral Ischemia and Reperfusion[J].Chinese Journal of Neuroimmunology and Neurology,1995,2(1):1-3,T001. |
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| Authors: | Wu Weiping Li Zhenzhou Kuang Peigen |
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| Abstract: | The local cerebral ischemia and reperfusion model of rats was made with thread embolism of middle cerebral artery.After 90 min ischemia following 30 min reperfusion,c-fos mRNA expression in rat brain was investigatied with in situ hybridization in ischemia following reperfusion and RSM-treated group.The results showed that c-fos gene expression in cerebral cortex and hippocampus of ischemic sides was significantly increased as compared to nonischemic sides (P<0. 001). Although c-fos gene expression in RSM treated-rat was also increased,it was significantly lower than that of ischemia following reperfusion group(P<0.05).The results indicated that c-fos gene expression in rat brain can be induced by cerebral ischemia following reperfusion and RSM may partly play a role in inhibition of c-fos gene expression during ischemia and reperfusion. |
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| Keywords: | ischemia and reperfusion RSM c-fos gene |
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