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Vaginal epithelioid malignant peripheral nerve sheath tumor nearly misdiagnosed as advanced cervical cancer: A case report
Institution:1. Department of Obstetrics and Gynecology, Kahramanmaraş Sütcü Imam University, Faculty of Medicine, Division of Gynecological Oncology, 46100, Onikişubat, Kahramanmaraş, Turkey;2. Department of Obstetrics and Gynecology, Istanbul Medeniyet University Göztepe Education and Research Hospital, Doktor Erkin Caddesi Kadıköy, İstanbul, Turkey;3. Department of Pathology, Faculty of Medicine, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadıköy, Istanbul, Turkey
Abstract:A 56-year-old woman was referred to our hospital with a pathological diagnosis of squamous cell carcinoma of the cervix. We performed a re-biopsy of the vaginal mass and cervical conization. The mass was originally reported as an epithelioid MPNST after re-biopsy. Strong diffuse S-100 positivity, epithelioid morphology of the lesion, and negativity to all other immune histochemical markers confirmed the diagnosis of epithelioid MPNST. Cervical conization specimen was negative for any neoplasms.
Keywords:Vaginal schwannoma  Vaginal epithelioid MPNST  Malignant peripheral nerve sheath tumors  Vaginal cancer  Spindle-to-epithelioid tumor
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