| 热分析法对固体药物对乙酰氨基酚分解动力学的研究 |
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| 引用本文： | 武凤兰,艾立成,苏德森.热分析法对固体药物对乙酰氨基酚分解动力学的研究[J].沈阳药科大学学报,1990(1). |
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| 作者姓名： | 武凤兰 艾立成 苏德森 |
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| 作者单位： | 沈阳药学院物理药学研究室
(武凤兰，艾立成)，沈阳药学院物理药学研究室(苏德森) |
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| 摘 要： | 采用差热分析(DTA)与差动扫描分析(DSC)两种热分析方法研究了固体药物对乙酰氮基酚的分解动力学,测定了此药物的热分解反应级数与分解活化能及频率因子。两种方法测得热分解反应级数均为1/3级,DTA法测得热分解活化能E为117.4kj·mol~(-1),频率因子A为6.69×10~7s~(-1)。DSC法测得热分解活化能E为118.38kj·mol~(-1),频率因子A为1.45×10~8S~(-1)。两种方法所得结果基本一致,且动力学方程线性相关性好,相关系数均在0.998以上。
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| 关 键 词： | 热分析法 对乙酰氨基酚 动力学 |
STUDY ON THE DECOMPOSITION KINETICS OF N-ACETYL AMINOPHENOL BY THERMAL ANALYSIS METHOD |
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| Wu Fenglan,Ai Licheng,Su Desen,Research.STUDY ON THE DECOMPOSITION KINETICS OF N-ACETYL AMINOPHENOL BY THERMAL ANALYSIS METHOD[J].Journal of Shenyang Pharmaceutical University,1990(1). |
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| Authors: | Wu Fenglan Ai Licheng Su Desen Research |
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| Institution: | Wu Fenglan,Ai Licheng,Su Desen,Research Department of physical Pharmacy,Shenyang College of pharmacy |
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| Abstract: | The kinetics of the decomposition of solid drug N-Acetyl amino Aminophenol
was studied by the method of DTA and DSC. Treaction order of thermal decomp-
osition, the frequency factor A and the activation energy E of thermal decoposition
were determined. The reaction orded of thrmal decomposition was 1/3. The activa-
tion energy E and frequency factor A were 117.41KJ.Mol~(-1) and 6.69×10~7
S~(-1), 118.38KJ.Mol~(-1) and 1.45×10~8.S~(-1) respectively. The corelation coefficients
of kinetic equation were above 0.998. |
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| Keywords: | Method of thermal analysis N-Acetyl aminophenol Kinetics |
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