阿德福韦酯联合香菇多糖治疗慢性乙型肝炎肝纤维化的疗效观察 |
| |
引用本文: | 王正根,何涛,黄文胤,欧阳征仁,卢放根.阿德福韦酯联合香菇多糖治疗慢性乙型肝炎肝纤维化的疗效观察[J].南华大学学报(医学版),2009,37(5):538-540. |
| |
作者姓名: | 王正根 何涛 黄文胤 欧阳征仁 卢放根 |
| |
作者单位: | 王正根(中南大学,湘雅附二医院,湖南,长沙,410011;南华大学,第二附属医院,消化科);何涛(南华大学,第二附属医院,消化科);黄文胤,欧阳征仁(南华大学,第二附属医院,B超室);卢放根(中南大学,湘雅附二医院,湖南,长沙,410011) |
| |
摘 要: | 目的观察香茹多糖联合阿德福韦酯(ADV)对慢性乙肝肝纤维化的疗效。方法将符合条件的慢性乙肝患者随机分为香茹多糖加ADV联合治疗组和ADV单一治疗组,疗程半年,观察治疗前后HBVDNA滴度、血清肝纤维化4项指标和超声影像学等指标变化。结果两组治疗后上述指标均较治疗前下降,且联合治疗组较单一治疗组改善更为明显,尤以HA、PⅢNP、IV—C、LN和门静脉血流速度等指标改善更明显(P〈0.05,P〈0.01)。结论ADV可改善慢性乙肝纤维化,而香茹多糖可有效增强ADV抗肝纤维化的疗效。
|
关 键 词: | 慢性乙型肝炎 肝纤维化 阿德福韦酯 香菇多糖 |
Therapeutic Effect of Lentinan in Combination With Adefovir Dipivoxil on Liver Fibrosis in Chronic Hepatitis B Patients |
| |
Institution: | WANG Zheng - gen, HE Tao, HUANG Wen - yin, et al ( The 2nd Xiangya Hospital, Central South University, Changsha, Hunan 421001, China ) |
| |
Abstract: | Objective To observe the influence of lentinan (LET) in combination with adefovir dipivoxil (ADV) on hver fibrosis indexes in hepatitis B e antigen positive adults with chronic hepatitis B. Methods Patients with chronic hepatitis B were randomly assigned to receive the treatment with adefovir or adefovir plus lentinan for a minimum of six months. The parameters, including diameter of portal vein and splenic vein ( Dpv and Dsv ), speed of blood flow in portal vein (Spv ) as well as liver fibrosis indexes, such as hyaluronic acid ( HA ), the procollagen type ⅢN - terminal propeptide (P ⅢNP), type Ⅳcollagen ( Ⅳ-C) and laminin (LN), were determined before and after treatment. Results The above mentioned parameters in the post -treatment was improved, compared with in the pro -treatment. Furthermore, after treatment the improvement in combination group was significantly superior to that in the ADV monotherapy group, especially the makers of HA, PⅢ NP, Ⅳ - C, LN and Spy. Conclusions Adefovir dipivoxil could improve the liver fibrosis in the chronic hepatitis B. Lentinan could efficiently enhance the anti - fibrotic effect of ADV on liver fibrosis of chronic hepatitis B patients. |
| |
Keywords: | chronic hepatitis B liver fibrosis lentinan adefovir dipivoxil |
本文献已被 维普 万方数据 等数据库收录! |
| 点击此处可从《南华大学学报(医学版)》浏览原始摘要信息 |
| 点击此处可从《南华大学学报(医学版)》下载免费的PDF全文 |
|