| 格列齐特渗透泵控释片的制备及犬体内药动学 |
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| 引用本文： | 赵诤,卢骏,冯岩,刘志东,高国义.格列齐特渗透泵控释片的制备及犬体内药动学[J].中国医药工业杂志,2009,40(8). |
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| 作者姓名： | 赵诤 卢骏 冯岩 刘志东 高国义 |
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| 作者单位： | 1. 天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津,300193
2. 北京汇诚瑞祥医药技术有限公司,北京,100050 |
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| 摘 要： | 研制了格列齐特渗透泵控释片,并评价了体外药物释放度.采用单剂量交叉试验考察Beagle犬口服格列齐特缓释片(参比制剂)和本品的药动学行为.结果表明,本品的体外释放曲线与参比制剂一致,犬体内药动学行为一致,相对生物利用度为(99.4±14.9)%.
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| 关 键 词： | 格列齐特 渗透泵控释片 制备 药动学 |
Preparation and Pharmacokinetics in Beagle Dogs of Gliclazide Osmotic Pump Controlled-release Tablets |
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| Authors: | ZHAO Zheng LU Jun FENG Yan LIU Zhidong GAO Guoyi |
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| Abstract: | The osmotic pump-based controlled-release tablets loaded with gliclazide were prepared. The in vitro release and pharmacokinetics in Beagle dogs orally administrated were compared between the gliclazide sustained- release tablets (Diamicron) (reference tablets) and the prepared controlled-release tablets (test tablets). Results showed that the in vitro release were similar and the relative bioavailability was (99.4±14.9) %. |
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| Keywords: | gliclazide osmotic pump-based controlled-release tablet preparation pharmacokinetics |
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