Loss of β2 microglobulin from the cell surface of cutaneous malignant and premalignant lesions |
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Authors: | MARLYN L. TURBITT RONA M. M. MACKIE |
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Affiliation: | Department of Dermatology, University of Glasgow |
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Abstract: | Biopsies from twenty-three patients with malignant skin lesions and from twenty-two patients with premalignant or benign skin lesions were stained for beta2 microglobulin by use of the immunoperoxidase technique. The results showed a significant loss of demonstrable surface beta2 microglobulin from the surface of malignant cells compared to benign, and a partial loss in the premalignant cases. This difference could prove to be a useful tool in the histological diagnosis of malignant skin lesions, and in assessing whether or not the lesion has been completely excised. |
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