| 异甘草酸镁联合拉米夫定防治HBsAg阳性的恶性血液病患者化疗后肝功能损伤的临床研究 |
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| 引用本文： | 肖蓉.异甘草酸镁联合拉米夫定防治HBsAg阳性的恶性血液病患者化疗后肝功能损伤的临床研究[J].现代预防医学,2011,38(24):5147-5148,5153. |
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| 作者姓名： | 肖蓉 |
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| 作者单位： | 四川省人民医院血液科,成都,610072 |
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| 摘 要： | 目的]观察异甘草酸镁联合拉米夫定对HBsAg阳性的恶性血液病患者化疗药物所致肝损害的疗效. 方法]60例接受化疗的HBsAg阳性的恶性血液病患者随机分为联合用药组与单纯拉米夫定组.联合组32例,给予异甘草酸镁联合拉米夫定；单纯用药组28例,仅给拉米夫定. 结果]联合组乙肝病毒再激活率与对照组相似,差异无统计学意义(x2＝0.019,P=0.89).而化疗后联合用药组肝功能损害总发生宰低于对照组(x2=5.363,P=0.021),因肝功能异常延迟化疗较对照组下降,差异有统计学意义(x2=4.774,P=0.029).结论]异甘草酸镁联合拉米夫定可明显减轻HBsAg阳性的恶性血液病患者的化疗相关性肝损害.
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| 关 键 词： | 化疗 肝功能异常 HBsAg阳性 恶性血液病 拉米夫定 异甘草酸镁 |
CLINICAL OBSERVATION OF MAGNESIUM ISOGLYCYRRHIZINATE AND LAMIVUDINE OF DYSFUNCTION OF LIVER AFTER CHEMOTHERAPY WITH MALIGNANT HEMATOLOGICAL SYSTEMIC DISEASES OF HBV CARRIERS |
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| XIAO Rong.CLINICAL OBSERVATION OF MAGNESIUM ISOGLYCYRRHIZINATE AND LAMIVUDINE OF DYSFUNCTION OF LIVER AFTER CHEMOTHERAPY WITH MALIGNANT HEMATOLOGICAL SYSTEMIC DISEASES OF HBV CARRIERS[J].Modern Preventive Medicine,2011,38(24):5147-5148,5153. |
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| Authors: | XIAO Rong |
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| Institution: | XIAO Rong.(Department of Hematology,Sichuan Province People’s Hospital,Chengdu 610072,China) |
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| Abstract: | Objective]To observe the efficacy of patients with liver dysfunction after chemotherapy with Malignant Hematological Systemic Diseases of HBV carriers.Methods]Sixty HBV carriers with Malignant Hematological Systemic Diseases patients were randomized into combination group(n = 32)and control group(n = 28). The combination group was treated by lamivudine treatment and magnesium isoglycyrrhizinate. The control group was only treated by oral lamivudine treatment.Results]The comparison between two group in th... |
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| Keywords: | Chemotherapy Dysfunction of liver HBV carrier Hematopoietic malignancies lamivudine Magnesium isoglycyrrhizinate |
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