| 高效液相色谱法测定多非利特胶囊的溶出度 |
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| 引用本文： | 程佩素.高效液相色谱法测定多非利特胶囊的溶出度[J].中国药房,2006,17(23):1822-1823. |
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| 作者姓名： | 程佩素 |
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| 作者单位： | 浙江温岭市第一人民医院药剂科,温岭市,317500 |
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| 摘 要： | 目的:建立以高效液相色谱法测定多非利特胶囊溶出度的方法。方法:色谱柱为DiamonsilC18,流动相为水-甲醇(56∶44,用冰醋酸调pH至3.4),检测波长为229nm。按峰面积外标法计算浓度,并以小杯法测定溶出度。结果:多非利特浓度在1～51μg/ml范围内线性关系良好(r=0.9999,n=7),加样回收率为97.55%(RSD=0.14%),3批样品45min平均溶出度均在90%以上。结论:本方法操作简便、快捷,结果准确。
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| 关 键 词： | 多非利特 高效液相色谱法 溶出度 |
| 文章编号： | 1001-0408(2006)23-1822-02 |
| 收稿时间： | 10 24 2006 12:00AM |
| 修稿时间： | 11 6 2006 12:00AM |
Determination of the Dissolution of Dofetilide Capsules by HPLC |
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| CHENG Peisu.Determination of the Dissolution of Dofetilide Capsules by HPLC[J].China Pharmacy,2006,17(23):1822-1823. |
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| Authors: | CHENG Peisu |
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| Abstract: | OBJECTIVE:To establish a HPLC method for the determination of the dissolution of dofetilide capsules.METHODS:The separation was performed on Diamonsil-C 18 column,with mobile phase consisted of water-methanol(56∶44,with pH adjusted to 3.4with glacial acetic acid)at a wavelength of 229nm.The concentration was computed using external reference method of peak area and the dissolution was determined by small cup method.RESULTS:The method showed a good linear relationship in the range of 1μg/ml～51μg/ml(r=0.9999,n=7),the average recovery was97.55%(RSD=0.14%),the mean dissolutions at45minute of the 3 batches of samples were all above 90%.CONCLUSION:The method is simple,rapid and accurate. |
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| Keywords: | Dofetilide HPLC Dissolution |
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