| 人胎盘提取物对甲基磺酸乙酯致果蝇伴性隐性致死突变的抑制作用 |
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| 引用本文： | 王福琳,张天亮,许百全,丁恬.人胎盘提取物对甲基磺酸乙酯致果蝇伴性隐性致死突变的抑制作用[J].山东大学学报(医学版),1998(2). |
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| 作者姓名： | 王福琳 张天亮 许百全 丁恬 |
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| 作者单位： | 山东医科大学公共卫生学院 |
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| 摘 要： | 以甲基磺酸乙酯（ＥＭＳ）为致突变的阳性对照物，观察了人胎盘提取物（ＨＰＥ）对ＥＭＳ致果蝇伴性隐性致死突变的抑制作用。结果表明，ＥＭＳ的致死突变率为９．０７１％；ＥＭＳ染毒后喂饲含１０％、５％和２．５％ＨＰＥ培养基的３组果蝇，其致死突变率分别为６．１８４％、６．７２０％和７．９０７％，与ＥＭＳ阳性组比较，大、中二剂量组明显降低，Ｐ＜０．０５。喂饲ＨＰＥ果蝇的精子、精细胞和精母细胞阶段的伴性隐性致死突变率分别为８．２３５％、６．６４９％和５．９０６％，均低于ＥＭＳ阳性组中各细胞阶段的致死突变率，Ｐ＜０．０５。表明ＨＰＥ可抑制ＥＭＳ的致基因突变作用，且对不同阶段的生殖细胞有一定的保护作用。
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| 关 键 词： | 胎盘提取物 甲基磺酸乙酯 基因，致死 抑制，遗传 果蝇 |
INHIBITORY EFFECT OF HUMAN PLACENTAL EXTRACTS ON SEX LINKED RECESSIVE LETHAL EFFECT IN DROSOPHIA MELANOGASTER INDUCED BY ETHYL METHANE SULFONATE |
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| Wang Fulin ,Zhang Tianliang ,Xu Baiquan ,et al.INHIBITORY EFFECT OF HUMAN PLACENTAL EXTRACTS ON SEX LINKED RECESSIVE LETHAL EFFECT IN DROSOPHIA MELANOGASTER INDUCED BY ETHYL METHANE SULFONATE[J].Journal of Shandong University:Health Sciences,1998(2). |
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| Authors: | Wang Fulin Zhang Tianliang Xu Baiquan |
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| Institution: | Wang Fulin 1,Zhang Tianliang 1,Xu Baiquan 2,et al |
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| Abstract: | Anti mutagenesis of Human Placental Extracts(HPE)was studied by means of SLRL test in Drosophlia melanogaster with the Ethyl methane sulfonate(EMS)as the positive control.10%,5% and 2.5% HPE were fed from the beginning of EMS poisoning.The lethal rates were 6.184%,6.720% and 7.907% respectively,with the first two being significantly different from 9.07% of the EMS( P <0.05).The rates of every brood were 8.235 %,6.649% and 5.906% individually,decreased obviously against that of EMS control( P <0.05).It could be concluded from the result that HPE could inhibit the damage on genetic materials done by EMS and it had a protecting effect on every stage of germ cells sperm,spermblast and spermatocype. |
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| Keywords: | Placental extracts Ethyl methane sulfonate genes lethal suppression genetic Drosophila melanogaster |
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