| 炔诺酮对入蜕膜雌、孕激素受体的作用 |
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| 引用本文： | 张俊慧 周剑萍. 炔诺酮对入蜕膜雌、孕激素受体的作用[J]. 生殖与避孕, 1996, 16(4): 259-262 |
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| 作者姓名： | 张俊慧 周剑萍 |
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| 作者单位： | 上海医科大学妇产科医院研究所 |
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| 摘 要： | 采用Ｄｃｃ法和酶联组化法，检测２７例随机分组的健康早孕妇女服用或未服炔诺酮的蜕膜组织中雌、孕激素受体，并进行定量与定位分析。结果表明：服用炔诺酮每天１５ｍｇ，连续５天，蜕膜组织中的雌激素受体含量降低。提示降调节雌激素受体可能是炔诺酮抗生育的机理之一。
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| 关 键 词： | 炔诺酮，雌激素受体，孕激素受体，蜕膜 |
The Effct of Norethisterone on Progesterone and Estrogen Receptor Concentration in Human Decidua on Early Pregnancy |
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| Zhang Jun-hui, Zhou Jian-ping, Lu Xiang-yun,Lu Hui-juan, Wang Jin. The Effct of Norethisterone on Progesterone and Estrogen Receptor Concentration in Human Decidua on Early Pregnancy[J]. Reproduction and Contraception, 1996, 16(4): 259-262 |
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| Authors: | Zhang Jun-hui Zhou Jian-ping Lu Xiang-yun Lu Hui-juan Wang Jin |
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| Abstract: | Decidual concentrations and binding sites of progesterone receptor(PR)and estrogen recepor (ER)were measured with dextran coated absorption (DCC) and cytochemical method. 27 women were randomly divided into control and experimental groups. Pregnancies were terminated by vacuum aspiration on 6th day after norethisterone use(5mg, 3 times daily ×5days). It was observed that norethisterone significantly decreased decidual cytosol ER content (P<0. 05). It seems that the down-regulation of decidual ER by norethisterone may be one of causes of anti-early pregnancy. |
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| Keywords: | Norethisterone Estrogen receptor Progesterone receptor Decidua |
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