| 卡维地洛逆转膀胱癌细胞株多药耐药性 |
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| 引用本文： | 张远宁,杨唐俊,王祥卫,刘素英. 卡维地洛逆转膀胱癌细胞株多药耐药性[J]. 中国癌症杂志, 2005, 15(2): 156-158 |
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| 作者姓名： | 张远宁 杨唐俊 王祥卫 刘素英 |
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| 作者单位： | 第三军医大学附属新桥医院泌尿外科,重庆,400037 |
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| 摘 要： | 目的：研究卡维地洛对人膀胱癌耐药细胞株BIU-87／ADM的多药耐药性逆转作用。方法：应用MTT法检测人膀胱癌耐药细胞株(BIU-87／ADM)的耐药性；将卡维地洛与多柔比星联合作用于B10-87和BIU-87／ADM细胞，检测细胞内多柔比星聚集量。结果：卡维地洛与多柔比星共同温育BIU-87／ADM细胞后．能使BIU-87／ADM细胞内多柔比星聚积量增加，与单用多柔比星比较，差异有显著性。结论：卡维地洛对多柔比星有增敏作用，卡维地洛可逆转人膀胱癌细胞株BIU-87／ADM的多药耐药性。
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| 关 键 词： | 膀胱癌 卡维地洛 多药耐药 |
| 文章编号： | 1007-3639(2005)02-0156-03 |
| 修稿时间： | 2004-07-12 |
Reversal effects of carvedilol on multidrug resistance in bladder cell lines |
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| ZHANG Yuan-ning,YANG Tang-jun,WANG Xiang-wei,et al. Reversal effects of carvedilol on multidrug resistance in bladder cell lines[J]. China Oncology, 2005, 15(2): 156-158 |
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| Authors: | ZHANG Yuan-ning YANG Tang-jun WANG Xiang-wei et al |
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| Abstract: | Purpose:To study the reversal effects on multidrug resistance in multidrug-resistent bladder cell lines BIU-87/ADM. Methods:The degree of drug-resistence was detected by MTTmethod; the concentration of ADM in cells BIU-87 and BIU-87/ADM was detected after the cells were treated by carvedilol and ADM. Results:Pretreatment by carvedilol increased the concentration of ADM in BIU-87/ADM cells, ,and the concentration was much higher than that in those cells treated by ADM only. Conclusions:Carvedilol can enhance the cytotoxic effect of ADM,and can reverse the multidrug resistance in bladder cancer lines BIU-87/ADM. |
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| Keywords: | bladder cancer carvedilol multidrug resistance |
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