| 氧化低密度脂蛋白与新诊断2型糖尿病患者胰岛素抵抗的相关性研究 |
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| 引用本文： | 郑淑红,吕肖锋. 氧化低密度脂蛋白与新诊断2型糖尿病患者胰岛素抵抗的相关性研究[J]. 中国全科医学, 2010, 13(11): 1167-1169 |
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| 作者姓名： | 郑淑红 吕肖锋 |
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| 作者单位： | 中国人民解放军北京军区总医院内分泌科,北京市,100070 |
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| 摘 要： | 目的 探索氧化低密度脂蛋白(oxLDL)与新诊断2型糖尿病(T2DM)胰岛素抵抗的关系.方法 选择39例新诊断2型糖尿病患者(DM组)和30例年龄、性别与DM组相匹配的健康者(NC组).用酶联免疫吸附法(ELISA法)检测两组血清oxLDL水平;葡萄糖氧化酶法检测空腹血糖(FBG);酶法测定总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C);用化学发光法检测空腹胰岛素(FINS).用稳态模型法评估两组胰岛素抵抗指数(HOMA-IR).结果 DM组HOMA-IR和oxLDL较NC组显著升高[(4.8±2.7)与(1.6±0.4),P＜0.01;(24.8±13.9)μg/dl与(11.0±8.2)μg/dl,P＜0.01].以HOMA-IR为因变量,进行多元线型回归Stepwise法分析,所得回归方程为HOMA-IR=1.735+1.127 LDL-C+0.44 FBG+0.047 oxLDL(P＜0.05).结论 oxLDL是2型糖尿病胰岛素抵抗的重要危险因子,可能促进了2型糖尿病患者胰岛素抵抗的发生和发展.
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| 关 键 词： | 氧化低密度脂蛋白 糖尿病,2型 胰岛素抵抗 |
Relationship of oxLDL and Insulin Resistance in New-diagnosed Type 2 Diabetes Mellitus |
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| ZHENG Shu-hong,LV Xiao-feng. Relationship of oxLDL and Insulin Resistance in New-diagnosed Type 2 Diabetes Mellitus[J]. Chinese General Practice, 2010, 13(11): 1167-1169 |
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| Authors: | ZHENG Shu-hong LV Xiao-feng |
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| Affiliation: | ZHENG+Shu-hong,LV+Xiao-feng.Department+of+Endocrinology,the+Military+General+Hospital+of+Beijing+PLA,Beijing+100070,China |
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| Abstract: | Objective To investigate the relationship of insulin resistance and oxidized low density lipoprotein(oxLDL) in type 2 diabetes mellitus(T2DM).Methods Thirty-nine newly-diagnosed T2DM patients(MD group) and 30 healthy subjects(NC group) were enrolled in this study.Serum oxLDL levels were detected by enzyme-linked immunosorbent assay(ELISA),fasting blood glucose(FBG) by glucose oxidase;total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(L... |
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| Keywords: | Oxidized low density lipoprotein Diabetes mellitus,type 2 Insulin resistance |
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